Seroatlas · Human Serome Atlas

GMNC

Geminin coiled-coil domain-containing protein 1

Also known as: GEMC1, GEMC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NCL1
Gene: GMNC
Ensembl: ENSG00000205835
Chromosome: 3
Canonical length: 334 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable chromatin binding activity. Predicted to be involved in negative regulation of cell cycle and regulation of DNA-templated DNA replication initiation. Predicted to act upstream of or within several processes, including cerebrospinal fluid circulation; multi-ciliated epithelial cell differentiation; and seminiferous tubule development. Predicted to be located in extracellular region. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

334 residues, UniProt reviewed canonical sequence.

>A6NCL1|GMNC
     1  MNTILPCQDQ YFVGGQSYNC PYSTTTSESS VDVSTETWVS FWAAGLLDNR ELQQAPQAQE
    61  SFSDSNFPLP DLCSWEEAQL SSQLYRNKQL QDTLVQKEEE LARLHEENNH LRQYLNSALV
   121  KCLEEKAKKL LSSDEFSKAY GKFRKGKRKS KEQRYSPAEI PHPKNAKRNL SSEFANCEEQ
   181  AGPPVDPWVL QTLGLKDLDT IDDTSSANYS ALASHPRRVA STFSQFPDDA VDYKNIPRED
   241  MPIDYRGDRT TPLHSTATHG EDFHILSQLS NPPVGLKTLP YYTAHVSPNK TEMAFSTSLS
   301  PHCNVKTHSF HQGQAFVRRD EEGGWKFTWV PKQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GMNC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 7.6 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 7.6 nTPM
liver: 3.9 nTPM
choroid plexus: 2.8 nTPM
kidney: 1.8 nTPM
testis: 0.9 nTPM
endometrium: 0.8 nTPM

Single-cell type

cardiomyocytes: 78 nCPM
late spermatids: 64 nCPM
choroid plexus epithelial cells: 57 nCPM
early spermatids: 56 nCPM
late primary spermatocytes: 43 nCPM
early primary spermatocytes: 40 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 5.8 nTPM
white matter: 4.8 nTPM
hypothalamus: 3.8 nTPM
midbrain: 1.6 nTPM
spinal cord: 1.5 nTPM
basal ganglia: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.55
gnomAD pLI: 0.45
gnomAD missense Z: 0.53
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Geminin coiled-coil domain-containing protein 1, central coiled-coil domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GMNC as an antibody target. Whether an autoantibody or antibody against GMNC could matter depends on whether native GMNC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GMNC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GMNC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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