GML
Glycosyl-phosphatidylinositol-anchored molecule-like protein
Also known as: GML_HUMAN, LY6DL
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q99445
- Gene
- GML
- Ensembl
- ENSG00000104499
- Chromosome
- 8
- Canonical length
- 158 aa
- Protein class
- Predicted intracellular proteins, Transporters
- Secretome location
- Intracellular and membrane
OverviewNCBI Gene
Predicted to be involved in DNA damage response, signal transduction by p53 class mediator; apoptotic process; and negative regulation of cell population proliferation. Predicted to be located in plasma membrane. Predicted to be extrinsic component of membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
158 residues, UniProt reviewed canonical sequence.
>Q99445|GML
1 MLLFALLLAM ELPLVAASAT MRAQWTYSLR CHDCAVINDF NCPNIRVCPY HIRRCMTISI
61 RINSRELLVY KNCTNNCTFV YAAEQPPEAP GKIFKTNSFY WVCCCNSMVC NAGGPTNLER
121 DMLPDEVTEE ELPEGTVRLG VSKLLLSFAS IIVSNILPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GML can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.45
- Highest tissue expression
- 182 nTPM
Expression across tissuesHPA
Tissue
- adrenal gland: 182 nTPM
- testis: 3.2 nTPM
- appendix: 0.2 nTPM
- pancreas: 0.1 nTPM
- adipose tissue: 0 nTPM
- amygdala: 0 nTPM
Single-cell type
- early primary spermatocytes: 69 nCPM
- oocytes: 41 nCPM
- undifferentiated spermatogonia: 34 nCPM
- early spermatids: 31 nCPM
- late primary spermatocytes: 17 nCPM
- t-cells: 13 nCPM
Immune cell
- MAIT T-cell: 0.4 nTPM
- gdT-cell: 0.2 nTPM
- memory CD8 T-cell: 0.2 nTPM
- NK-cell: 0.2 nTPM
- memory CD4 T-cell: 0.1 nTPM
- basophil: 0 nTPM
Brain region
- basal ganglia: 6.3 nTPM
- hippocampal formation: 3.3 nTPM
- cerebral cortex: 1.4 nTPM
- thalamus: 1.1 nTPM
- white matter: 0.3 nTPM
- medulla oblongata: 0.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.47
- gnomAD pLI
- 0.22
- gnomAD missense Z
- 0
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- apoptotic process
- DNA damage response, signal transduction by p53 class mediator
- negative regulation of cell population proliferation
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GML as an antibody target. Whether an autoantibody or antibody against GML could matter depends on whether native GML is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GML is annotated at the cell surface, where native GML is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label GML as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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