Seroatlas · Human Serome Atlas

GLYCTK

Glycerate kinase

Also known as: GLCTK_HUMAN, HBEBP2, HBEBP4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IVS8
Gene: GLYCTK
Ensembl: ENSG00000168237
Chromosome: 3
Canonical length: 523 aa
Protein class: Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location: Golgi apparatus,Cytosol,Rods & Rings

OverviewNCBI Gene

This locus encodes a member of the glycerate kinase type-2 family. The encoded enzyme catalyzes the phosphorylation of (R)-glycerate and may be involved in serine degradation and fructose metabolism. Decreased activity of the encoded enzyme may be associated with the disease D-glyceric aciduria. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

523 residues, UniProt reviewed canonical sequence.

>Q8IVS8|GLYCTK
     1  MAAALQVLPR LARAPLHPLL WRGSVARLAS SMALAEQARQ LFESAVGAVL PGPMLHRALS
    61  LDPGGRQLKV RDRNFQLRQN LYLVGFGKAV LGMAAAAEEL LGQHLVQGVI SVPKGIRAAM
   121  ERAGKQEMLL KPHSRVQVFE GAEDNLPDRD ALRAALAIQQ LAEGLTADDL LLVLISGGGS
   181  ALLPAPIPPV TLEEKQTLTR LLAARGATIQ ELNTIRKALS QLKGGGLAQA AYPAQVVSLI
   241  LSDVVGDPVE VIASGPTVAS SHNVQDCLHI LNRYGLRAAL PRSVKTVLSR ADSDPHGPHT
   301  CGHVLNVIIG SNVLALAEAQ RQAEALGYQA VVLSAAMQGD VKSMAQFYGL LAHVARTRLT
   361  PSMAGASVEE DAQLHELAAE LQIPDLQLEE ALETMAWGRG PVCLLAGGEP TVQLQGSGRG
   421  GRNQELALRV GAELRRWPLG PIDVLFLSGG TDGQDGPTEA AGAWVTPELA SQAAAEGLDI
   481  ATFLAHNDSH TFFCCLQGGA HLLHTGMTGT NVMDTHLLFL RPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GLYCTK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 139 nTPM

Expression across tissuesHPA

Tissue

liver: 139 nTPM
duodenum: 21 nTPM
small intestine: 18 nTPM
kidney: 15 nTPM
adipose tissue: 9.8 nTPM
colon: 7.2 nTPM

Single-cell type

hepatocytes: 240 nCPM
enterocytes: 101 nCPM
enteric transient amplifying cells: 35 nCPM
proximal tubule cells: 28 nCPM
colonocytes: 27 nCPM
adipocytes: 24 nCPM

Immune cell

eosinophil: 6.6 nTPM
T-reg: 6.6 nTPM
gdT-cell: 5.6 nTPM
myeloid DC: 5.6 nTPM
classical monocyte: 5.2 nTPM
memory CD8 T-cell: 4.9 nTPM

Brain region

cerebral cortex: 7.7 nTPM
medulla oblongata: 7.7 nTPM
hypothalamus: 7.5 nTPM
pons: 7.4 nTPM
white matter: 7.2 nTPM
midbrain: 6.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GLYCTK.

Disease | AllUniProt

Conditions GLYCTK is implicated in, by any mechanism.

D-glyceric aciduria (D-GA) MIM:220120

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 247 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

D-Glyceric aciduria

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.6
gnomAD pLI: 0
gnomAD missense Z: -0.23
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ATP binding
glycerate kinase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

MOFRL domain
MOFRL-associated domain
Glycerate kinase-like, C-terminal domain superfamily
Glycerate kinase, N-terminal domain superfamily
MOFRL domain-containing protein
MOFRL family
Domain of unknown function (DUF4147)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GLYCTK as an antibody target. Whether an autoantibody or antibody against GLYCTK could matter depends on whether native GLYCTK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GLYCTK is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GLYCTK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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