Seroatlas · Human Serome Atlas

GLTP

Glycolipid transfer protein

Also known as: GLTP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NZD2
Gene: GLTP
Ensembl: ENSG00000139433
Chromosome: 12
Canonical length: 209 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

The protein encoded by this gene is similar to bovine and porcine proteins which accelerate transfer of certain glycosphingolipids and glyceroglycolipids between membranes. It is thought to be a cytoplasmic protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

209 residues, UniProt reviewed canonical sequence.

>Q9NZD2|GLTP
     1  MALLAEHLLK PLPADKQIET GPFLEAVSHL PPFFDCLGSP VFTPIKADIS GNITKIKAVY
    61  DTNPAKFRTL QNILEVEKEM YGAEWPKVGA TLALMWLKRG LRFIQVFLQS ICDGERDENH
   121  PNLIRVNATK AYEMALKKYH GWIVQKIFQA ALYAAPYKSD FLKALSKGQN VTEEECLEKI
   181  RLFLVNYTAT IDVIYEMYTQ MNAELNYKV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GLTP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 315 nTPM

Expression across tissuesHPA

Tissue

esophagus: 315 nTPM
skin: 257 nTPM
spinal cord: 194 nTPM
vagina: 167 nTPM
cervix: 110 nTPM
tonsil: 101 nTPM

Single-cell type

esophageal apical cells: 3,042 nCPM
esophageal suprabasal cells: 1,065 nCPM
suprabasal keratinocytes: 637 nCPM
esophageal basal cells: 303 nCPM
syncytiotrophoblasts: 299 nCPM
ocular epithelial cells: 193 nCPM

Immune cell

intermediate monocyte: 66 nTPM
classical monocyte: 66 nTPM
non-classical monocyte: 57 nTPM
gdT-cell: 52 nTPM
myeloid DC: 49 nTPM
memory CD8 T-cell: 46 nTPM

Brain region

white matter: 223 nTPM
medulla oblongata: 174 nTPM
basal ganglia: 146 nTPM
cerebellum: 139 nTPM
pons: 133 nTPM
midbrain: 129 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.83
gnomAD pLI: 0.11
gnomAD missense Z: 0.53
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GLTP as an antibody target. Whether an autoantibody or antibody against GLTP could matter depends on whether native GLTP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GLTP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GLTP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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