Seroatlas · Human Serome Atlas

GLT8D2

Glycosyltransferase 8 domain-containing protein 2

Also known as: FLJ31494, GL8D2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H1C3
Gene: GLT8D2
Ensembl: ENSG00000120820
Chromosome: 12
Canonical length: 349 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

349 residues, UniProt reviewed canonical sequence.

>Q9H1C3|GLT8D2
     1  MALLRKINQV LLFLLIVTLC VILYKKVHKG TVPKNDADDE SETPEELEEE IPVVICAAAG
    61  RMGATMAAIN SIYSNTDANI LFYVVGLRNT LTRIRKWIEH SKLREINFKI VEFNPMVLKG
   121  KIRPDSSRPE LLQPLNFVRF YLPLLIHQHE KVIYLDDDVI VQGDIQELYD TTLALGHAAA
   181  FSDDCDLPSA QDINRLVGLQ NTYMGYLDYR KKAIKDLGIS PSTCSFNPGV IVANMTEWKH
   241  QRITKQLEKW MQKNVEENLY SSSLGGGVAT SPMLIVFHGK YSTINPLWHI RHLGWNPDAR
   301  YSEHFLQEAK LLHWNGRHKP WDFPSVHNDL WESWFVPDPA GIFKLNHHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GLT8D2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

ovary: 55 nTPM
blood vessel: 41 nTPM
gallbladder: 34 nTPM
cervix: 28 nTPM
endometrium: 26 nTPM
thyroid gland: 25 nTPM

Single-cell type

leydig cells: 98 nCPM
ovarian stromal cells: 94 nCPM
peritubular myoid cells: 83 nCPM
breast myoepithelial cells: 78 nCPM
fibro-adipogenic progenitors: 73 nCPM
fibroblasts: 70 nCPM

Immune cell

gdT-cell: 0.3 nTPM
memory CD8 T-cell: 0.2 nTPM
intermediate monocyte: 0.1 nTPM
MAIT T-cell: 0.1 nTPM
memory B-cell: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM

Brain region

choroid plexus: 21 nTPM
cerebral cortex: 7.5 nTPM
basal ganglia: 6.6 nTPM
hippocampal formation: 6.3 nTPM
white matter: 6.1 nTPM
amygdala: 5.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.46
gnomAD pLI: 0
gnomAD missense Z: 0.46
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

UDP-glycosyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GLT8D2 as an antibody target. Whether an autoantibody or antibody against GLT8D2 could matter depends on whether native GLT8D2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GLT8D2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GLT8D2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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