Seroatlas · Human Serome Atlas

GLT1D1

Glycosyltransferase 1 domain-containing protein 1

Also known as: FLJ31978, GL1D1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96MS3
Gene: GLT1D1
Ensembl: ENSG00000151948
Chromosome: 12
Canonical length: 346 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Cytosol
Secretome location: Secreted to blood

OverviewNCBI Gene

Predicted to enable glycosyltransferase activity. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

346 residues, UniProt reviewed canonical sequence.

>Q96MS3|GLT1D1
     1  MRLLFLAVLR PHTGNAVTAQ RVRAHLEAAG HVCVLKDAFD FESRSEIANL ILAENCEAAL
    61  ALHLYRGGRL LQGHRIPFGV IFGGTDVNED ANQAEKNTVM GRVLEEARFA VAFTESMKEM
   121  AQAQWPHAKG KVYVQSQGIA TTPNAAFNWN TFLQRSEINQ SADNLHIFLL ICGLRQVKDP
   181  LYLVDAFSAW HQEEPNVHLV IVGPEVDPVF TREVKAKVKR AAGVRLIGEM PQEDLHAVVK
   241  NCFAVVNSSV SEGMSAAILE AMDLEVPVLA RNIPGNAAVV KHEVTGLLFS NPQEFVHLAK
   301  RLVSDPALEK EIVVNGREYV RMYHSWQVER DTYQQLIRKL EGSTED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GLT1D1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 27 nTPM
liver: 26 nTPM
choroid plexus: 20 nTPM
cerebral cortex: 15 nTPM
testis: 15 nTPM
basal ganglia: 14 nTPM

Single-cell type

neutrophils: 2,708 nCPM
neutrophil progenitors: 680 nCPM
pdcs: 183 nCPM
monocytes: 148 nCPM
choroid plexus epithelial cells: 139 nCPM
late spermatids: 79 nCPM

Immune cell

neutrophil: 37 nTPM
classical monocyte: 6.3 nTPM
intermediate monocyte: 3.6 nTPM
plasmacytoid DC: 2.3 nTPM
non-classical monocyte: 2 nTPM
total PBMC: 1.6 nTPM

Brain region

hypothalamus: 35 nTPM
cerebral cortex: 31 nTPM
basal ganglia: 25 nTPM
white matter: 24 nTPM
choroid plexus: 22 nTPM
hippocampal formation: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.42
gnomAD pLI: 0
gnomAD missense Z: 0
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

glycosyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Glycosyl transferase, family 1
Glycosyl transferases group 1
Glycosyltransferase group 1 domain-containing protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GLT1D1 as an antibody target. Whether an autoantibody or antibody against GLT1D1 could matter depends on whether native GLT1D1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GLT1D1 is annotated as secreted, so native GLT1D1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label GLT1D1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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