Seroatlas · Human Serome Atlas

GLMP

Glycosylated lysosomal membrane protein

Also known as: C1orf85, GLMP_HUMAN, MGC31963, NCU-G1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WWB7
Gene: GLMP
Ensembl: ENSG00000198715
Chromosome: 1
Canonical length: 406 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Involved in positive regulation of transcription by RNA polymerase II. Located in cytosol; lysosome; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

406 residues, UniProt reviewed canonical sequence.

>Q8WWB7|GLMP
     1  MRGSVECTWG WGHCAPSPLL LWTLLLFAAP FGLLGEKTRQ VSLEVIPNWL GPLQNLLHIR
    61  AVGTNSTLHY VWSSLGPLAV VMVATNTPHS TLSVNWSLLL SPEPDGGLMV LPKDSIQFSS
   121  ALVFTRLLEF DSTNVSDTAA KPLGRPYPPY SLADFSWNNI TDSLDPATLS ATFQGHPMND
   181  PTRTFANGSL AFRVQAFSRS SRPAQPPRLL HTADTCQLEV ALIGASPRGN RSLFGLEVAT
   241  LGQGPDCPSM QEQHSIDDEY APAVFQLDQL LWGSLPSGFA QWRPVAYSQK PGGRESALPC
   301  QASPLHPALA YSLPQSPIVR AFFGSQNNFC AFNLTFGAST GPGYWDQHYL SWSMLLGVGF
   361  PPVDGLSPLV LGIMAVALGA PGLMLLGGGL VLLLHHKKYS EYQSIN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GLMP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 64 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 64 nTPM
liver: 58 nTPM
prostate: 55 nTPM
kidney: 51 nTPM
choroid plexus: 47 nTPM
placenta: 45 nTPM

Single-cell type

hofbauer cells: 335 nCPM
esophageal apical cells: 106 nCPM
kupffer cells: 94 nCPM
extravillous trophoblasts: 92 nCPM
hepatocytes: 84 nCPM
syncytiotrophoblasts: 81 nCPM

Immune cell

intermediate monocyte: 75 nTPM
classical monocyte: 71 nTPM
non-classical monocyte: 56 nTPM
T-reg: 44 nTPM
total PBMC: 37 nTPM
basophil: 35 nTPM

Brain region

choroid plexus: 31 nTPM
thalamus: 21 nTPM
pons: 18 nTPM
white matter: 16 nTPM
hypothalamus: 15 nTPM
midbrain: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.45
gnomAD pLI: 0
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Glycosylated lysosomal membrane protein
Lysosomal transcription factor, NCU-G1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GLMP as an antibody target. Whether an autoantibody or antibody against GLMP could matter depends on whether native GLMP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GLMP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GLMP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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