Seroatlas · Human Serome Atlas

GLI4

Zinc finger protein GLI4

Also known as: GLI4_HUMAN, HKR4, ZNF928

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P10075
Gene: GLI4
Ensembl: ENSG00000250571
Chromosome: 8
Canonical length: 376 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytokinetic bridge

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

376 residues, UniProt reviewed canonical sequence.

>P10075|GLI4
     1  MAALGDIQES PSVPSPVSLS SPGTPGTQHH EPQLHLHGHQ HGSPGSSPKV LSQPSDLDLQ
    61  DVEEVEIGRD TFWPDSEPKP EQAPRSPGSQ APDEGAGGAL RSLLRSLPRR ARCSAGFGPE
   121  SSAERPAGQP PGAVPCAQPR GAWRVTLVQQ AAAGPEGAPE RAAELGVNFG RSRQGSARGA
   181  KPHRCEACGK SFKYNSLLLK HQRIHTGEKP YACHECGKRF RGWSGFIQHH RIHTGEKPYE
   241  CGQCGRAFSH SSHFTQHLRI HNGEKPYKCG ECGQAFSQSS NLVRHQRLHT GEKPYACSQC
   301  GKAFIWSSVL IEHQRIHTGE KPYECSDCGK AFRGRSHFFR HLRTHTGEKP FACGACGKAF
   361  GQSSQLIQHQ RVHYRE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GLI4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

hippocampal formation: 23 nTPM
basal ganglia: 22 nTPM
amygdala: 20 nTPM
cerebral cortex: 19 nTPM
cerebellum: 17 nTPM
hypothalamus: 17 nTPM

Single-cell type

esophageal suprabasal cells: 28 nCPM
esophageal basal cells: 25 nCPM
oocytes: 23 nCPM
smooth muscle cells: 22 nCPM
respiratory secretory cells: 21 nCPM
suprabasal keratinocytes: 20 nCPM

Immune cell

NK-cell: 1.1 nTPM
plasmacytoid DC: 1.1 nTPM
T-reg: 0.7 nTPM
MAIT T-cell: 0.6 nTPM
naive CD4 T-cell: 0.6 nTPM
memory B-cell: 0.4 nTPM

Brain region

cerebral cortex: 23 nTPM
amygdala: 21 nTPM
hippocampal formation: 20 nTPM
cerebellum: 20 nTPM
thalamus: 18 nTPM
pons: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0
gnomAD missense Z: -0.68
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of DNA-templated transcription

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GLI4 as an antibody target. Whether an autoantibody or antibody against GLI4 could matter depends on whether native GLI4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GLI4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GLI4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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