Seroatlas · Human Serome Atlas

GLG1

Golgi apparatus protein 1

Also known as: CFR-1, ESL-1, GSLG1_HUMAN, MG-160

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92896
Gene: GLG1
Ensembl: ENSG00000090863
Chromosome: 16
Canonical length: 1179 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Golgi apparatus,Mid piece,Principal piece,End piece

OverviewNCBI Gene

Predicted to enable fibroblast growth factor binding activity. Predicted to act upstream of or within several processes, including negative regulation of protein processing; negative regulation of transforming growth factor beta receptor signaling pathway; and regulation of chondrocyte differentiation. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1179 residues, UniProt reviewed canonical sequence.

>Q92896|GLG1
     1  MAACGRVRRM FRLSAALHLL LLFAAGAEKL PGQGVHSQGQ GPGANFVSFV GQAGGGGPAG
    61  QQLPQLPQSS QLQQQQQQQQ QQQQPQPPQP PFPAGGPPAR RGGAGAGGGW KLAEEESCRE
   121  DVTRVCPKHT WSNNLAVLEC LQDVREPENE ISSDCNHLLW NYKLNLTTDP KFESVAREVC
   181  KSTITEIKEC ADEPVGKGYM VSCLVDHRGN ITEYQCHQYI TKMTAIIFSD YRLICGFMDD
   241  CKNDINILKC GSIRLGEKDA HSQGEVVSCL EKGLVKEAEE REPKIQVSEL CKKAILRVAE
   301  LSSDDFHLDR HLYFACRDDR ERFCENTQAG EGRVYKCLFN HKFEESMSEK CREALTTRQK
   361  LIAQDYKVSY SLAKSCKSDL KKYRCNVENL PRSREARLSY LLMCLESAVH RGRQVSSECQ
   421  GEMLDYRRML MEDFSLSPEI ILSCRGEIEH HCSGLHRKGR TLHCLMKVVR GEKGNLGMNC
   481  QQALQTLIQE TDPGADYRID RALNEACESV IQTACKHIRS GDPMILSCLM EHLYTEKMVE
   541  DCEHRLLELQ YFISRDWKLD PVLYRKCQGD ASRLCHTHGW NETSEFMPQG AVFSCLYRHA
   601  YRTEEQGRRL SRECRAEVQR ILHQRAMDVK LDPALQDKCL IDLGKWCSEK TETGQELECL
   661  QDHLDDLVVE CRDIVGNLTE LESEDIQIEA LLMRACEPII QNFCHDVADN QIDSGDLMEC
   721  LIQNKHQKDM NEKCAIGVTH FQLVQMKDFR FSYKFKMACK EDVLKLCPNI KKKVDVVICL
   781  STTVRNDTLQ EAKEHRVSLK CRRQLRVEEL EMTEDIRLEP DLYEACKSDI KNFCSAVQYG
   841  NAQIIECLKE NKKQLSTRCH QKVFKLQETE MMDPELDYTL MRVCKQMIKR FCPEADSKTM
   901  LQCLKQNKNS ELMDPKCKQM ITKRQITQNT DYRLNPMLRK ACKADIPKFC HGILTKAKDD
   961  SELEGQVISC LKLRYADQRL SSDCEDQIRI IIQESALDYR LDPQLQLHCS DEISSLCAEE
  1021  AAAQEQTGQV EECLKVNLLK IKTELCKKEV LNMLKESKAD IFVDPVLHTA CALDIKHHCA
  1081  AITPGRGRQM SCLMEALEDK RVRLQPECKK RLNDRIEMWS YAAKVAPADG FSDLAMQVMT
  1141  SPSKNYILSV ISGSICILFL IGLMCGRITK RVTRELKDR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GLG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 42 nTPM
testis: 38 nTPM
ovary: 37 nTPM
pancreas: 33 nTPM
parathyroid gland: 32 nTPM
endometrium: 30 nTPM

Single-cell type

proximal tubule cells: 472 nCPM
myonuclei: 385 nCPM
pancreatic acinar cells: 347 nCPM
tuft cells: 323 nCPM
gonadotrophs: 310 nCPM
lactotrophs: 292 nCPM

Immune cell

naive CD4 T-cell: 28 nTPM
memory CD4 T-cell: 24 nTPM
naive CD8 T-cell: 23 nTPM
T-reg: 21 nTPM
memory CD8 T-cell: 21 nTPM
non-classical monocyte: 20 nTPM

Brain region

midbrain: 73 nTPM
hypothalamus: 71 nTPM
white matter: 70 nTPM
medulla oblongata: 68 nTPM
thalamus: 68 nTPM
basal ganglia: 64 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.21
gnomAD pLI: 1
gnomAD missense Z: 2.07
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Cysteine-rich Golgi apparatus protein 1 repeat
Cysteine-rich Golgi apparatus protein 1 repeat, eukaryote
Golgi apparatus protein 1
Cysteine rich repeat

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GLG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

OSBPL8

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GLG1 as an antibody target. Whether an autoantibody or antibody against GLG1 could matter depends on whether native GLG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GLG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GLG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...