GLCE

Protein identityUniProt · HPA

UniProt accession

O94923

Gene

GLCE

Ensembl

ENSG00000138604

Chromosome

15

Canonical length

617 aa

Protein class

Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Mitochondria

Quaternary structure

Homodimer

OverviewNCBI Gene

Enables calcium ion binding activity; heparosan-N-sulfate-glucuronate 5-epimerase activity; and protein homodimerization activity. Involved in heparan sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Implicated in cerebrovascular disease and hypertension. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

617 residues, UniProt reviewed canonical sequence.

>O94923|GLCE
     1  MRCLAARVNY KTLIIICALF TLVTVLLWNK CSSDKAIQFP RRSSSGFRVD GFEKRAAASE
    61  SNNYMNHVAK QQSEEAFPQE QQKAPPVVGG FNSNVGSKVL GLKYEEIDCL INDEHTIKGR
   121  REGNEVFLPF TWVEKYFDVY GKVVQYDGYD RFEFSHSYSK VYAQRAPYHP DGVFMSFEGY
   181  NVEVRDRVKC ISGVEGVPLS TQWGPQGYFY PIQIAQYGLS HYSKNLTEKP PHIEVYETAE
   241  DRDKNKPNDW TVPKGCFMAN VADKSRFTNV KQFIAPETSE GVSLQLGNTK DFIISFDLKF
   301  LTNGSVSVVL ETTEKNQLFT IHYVSNAQLI AFKERDIYYG IGPRTSWSTV TRDLVTDLRK
   361  GVGLSNTKAV KPTKIMPKKV VRLIAKGKGF LDNITISTTA HMAAFFAASD WLVRNQDEKG
   421  GWPIMVTRKL GEGFKSLEPG WYSAMAQGQA ISTLVRAYLL TKDHIFLNSA LRATAPYKFL
   481  SEQHGVKAVF MNKHDWYEEY PTTPSSFVLN GFMYSLIGLY DLKETAGEKL GKEARSLYER
   541  GMESLKAMLP LYDTGSGTIY DLRHFMLGIA PNLARWDYHT THINQLQLLS TIDESPVFKE
   601  FVKRWKSYLK GSRAKHN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GLCE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.31

Highest tissue expression

41 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.44

gnomAD pLI

0.65

gnomAD missense Z

1.71

DepMap mean gene effect

-0.1

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• heparan sulfate proteoglycan biosynthetic process
• heparin proteoglycan biosynthetic process
• negative regulation of cell projection organization
• positive regulation of cell population proliferation
• positive regulation of SMAD protein signal transduction

Molecular functions

• calcium ion binding
• protein homodimerization activity
• racemase and epimerase activity, acting on carbohydrates and derivatives
• heparosan-N-sulfate-glucuronate 5-epimerase activity

Cellular components

• Golgi apparatus
• Golgi membrane

Protein domainsUniProt · Pfam · InterPro

• D-glucuronyl C5-epimerase, C-terminal
• D-glucuronyl C5-epimerase
• D-glucuronyl C5-epimerase, beta-sandwich domain
• D-glucuronyl C5-epimerase C-terminus
• D-glucuronyl C5-epimerase, beta-sandwich domain

KeywordsUniProt

• Calcium
• Glycoprotein
• Golgi apparatus
• Isomerase
• Membrane
• Metal-binding
• Signal-anchor
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of GLCE in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• HS2ST1