Seroatlas · Human Serome Atlas

GLCCI1

Glucocorticoid-induced transcript 1 protein

Also known as: FAM117C, GIG18, GLCI1_HUMAN, TSSN1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86VQ1
Gene
GLCCI1
Ensembl
ENSG00000106415
Chromosome
7
Canonical length
547 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoli

OverviewNCBI Gene

This gene encodes a protein of unknown function. Expression of this gene is induced by glucocorticoids and may be an early marker for glucocorticoid-induced apoptosis. Single nucleotide polymorphisms in this gene are associated with a decreased response to inhaled glucocorticoids in asthmatic patients. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

547 residues, UniProt reviewed canonical sequence.

>Q86VQ1|GLCCI1
     1  MSTASSSSSS SSSQTPHPPS QRMRRSAAGS PPAVAAAGSG NGAGGGGGVG CAPAAGAGRL
    61  LQPIRATVPY QLLRGSQHSP TRPPVAAAAA SLGSLPGPGA ARGPSPSSPT PPAAAAPAEQ
   121  APRAKGRPRR SPESHRRSSS PERRSPGSPV CRADKAKSQQ VRTSSTIRRT SSLDTITGPY
   181  LTGQWPRDPH VHYPSCMKDK ATQTPSCWAE EGAEKRSHQR SASWGSADQL KEQIAKLRQQ
   241  LQRSKQSSRH SKEKDRQSPL HGNHITISHT QATGSRSVPM PLSNISVPKS SVSRVPCNVE
   301  GISPELEKVF IKENNGKEEV SKPLDIPDGR RAPLPAHYRS SSTRSIDTQT PSVQERSSSC
   361  SSHSPCVSPF CPPESQDGSP CSTEDLLYDR DKDSGSSSPL PKYASSPKPN NSYMFKREPP
   421  EGCERVKVFE EMASRQPISA PLFSCPDKNK VNFIPTGSAF CPVKLLGPLL PASDLMLKNS
   481  PNSGQSSALA TLTVEQLSSR VSFTSLSDDT STAGSMEASV QQPSQQQQLL QELQGEDHIS
   541  AQNYVII

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GLCCI1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.71
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 31 nTPM
  • thyroid gland: 16 nTPM
  • tonsil: 14 nTPM
  • lymph node: 11 nTPM
  • testis: 10 nTPM
  • lung: 8.4 nTPM

Single-cell type

  • plasma cells: 789 nCPM
  • renal collecting duct intercalated cells: 469 nCPM
  • adrenal medulla cells: 457 nCPM
  • oligodendrocyte progenitor cells: 388 nCPM
  • adipocytes: 354 nCPM
  • transitional alveolar cells: 350 nCPM

Immune cell

  • NK-cell: 2.1 nTPM
  • basophil: 2 nTPM
  • T-reg: 2 nTPM
  • naive B-cell: 1.4 nTPM
  • gdT-cell: 1.1 nTPM
  • memory CD4 T-cell: 1.1 nTPM

Brain region

  • cerebral cortex: 29 nTPM
  • cerebellum: 26 nTPM
  • white matter: 25 nTPM
  • basal ganglia: 23 nTPM
  • hypothalamus: 20 nTPM
  • thalamus: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.57
gnomAD pLI
0.06
gnomAD missense Z
0.13
DepMap mean gene effect
0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GLCCI1 as an antibody target. Whether an autoantibody or antibody against GLCCI1 could matter depends on whether native GLCCI1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GLCCI1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GLCCI1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GLCCI1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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