Seroatlas · Human Serome Atlas

GKAP1

G kinase-anchoring protein 1

Also known as: FKSG21, GKAP1_HUMAN, GKAP42

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5VSY0
Gene
GKAP1
Ensembl
ENSG00000165113
Chromosome
9
Canonical length
366 aa
Protein class
Predicted intracellular proteins
Subcellular location
Centriolar satellite,Cytosol

OverviewNCBI Gene

This gene encodes a protein that is highly similar to the mouse cGMP-dependent protein kinase anchoring protein 42kDa. The mouse protein has been found to localize with the Golgi and recruit cGMP-dependent protein kinase I alpha to the Golgi in mouse testes. It is thought to play a role in germ cell development. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Canonical amino-acid sequenceUniProt

366 residues, UniProt reviewed canonical sequence.

>Q5VSY0|GKAP1
     1  MASAVLSSVP TTASRFALLQ VDSGSGSDSE PGKGKGRNTG KSQTLGSKST TNEKKREKRR
    61  KKKEQQQSEA NELRNLAFKK IPQKSSHAVC NAQHDLPLSN PVQKDSREEN WQEWRQRDEQ
   121  LTSEMFEADL EKALLLSKLE YEEHKKEYED AENTSTQSKV MNKKDKRKNH QGKDRPLTVS
   181  LKDFHSEDHI SKKTEELSSS QTLSHDGGFF NRLEDDVHKI LIREKRREQL TEYNGTDNCT
   241  AHEHNQEVVL KDGRIERLKL ELERKDAEIQ KLKNVITQWE AKYKEVKARN AQLLKMLQEG
   301  EMKDKAEILL QVDESQSIKN ELTIQVTSLH AALEQERSKV KVLQAELAKY QGGRKGKRNS
   361  ESDQCR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GKAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
187 nTPM

Expression across tissuesHPA

Tissue

  • testis: 187 nTPM
  • skeletal muscle: 47 nTPM
  • tongue: 25 nTPM
  • retina: 21 nTPM
  • cerebellum: 19 nTPM
  • choroid plexus: 14 nTPM

Single-cell type

  • late primary spermatocytes: 1,879 nCPM
  • early spermatids: 1,298 nCPM
  • late spermatids: 668 nCPM
  • retinal horizontal cells: 226 nCPM
  • early primary spermatocytes: 211 nCPM
  • choroid plexus epithelial cells: 208 nCPM

Immune cell

  • NK-cell: 2 nTPM
  • basophil: 1.2 nTPM
  • neutrophil: 1.1 nTPM
  • memory B-cell: 0.7 nTPM
  • naive CD8 T-cell: 0.7 nTPM
  • naive B-cell: 0.6 nTPM

Brain region

  • cerebellum: 43 nTPM
  • choroid plexus: 40 nTPM
  • white matter: 35 nTPM
  • basal ganglia: 29 nTPM
  • hypothalamus: 29 nTPM
  • pons: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0.06
gnomAD missense Z
0.73
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • G kinase-anchoring protein 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GKAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GKAP1 as an antibody target. Whether an autoantibody or antibody against GKAP1 could matter depends on whether native GKAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GKAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GKAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GKAP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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