Seroatlas · Human Serome Atlas

GJE1

Gap junction epsilon-1 protein

Also known as: CX23, CXE1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NN92
Gene
GJE1
Ensembl
ENSG00000203733
Chromosome
6
Canonical length
205 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable gap junction channel activity. Predicted to be involved in cell-cell signaling. Predicted to act upstream of or within cell morphogenesis; lens development in camera-type eye; and organ growth. Predicted to be located in plasma membrane. Predicted to be part of connexin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

205 residues, UniProt reviewed canonical sequence.

>A6NN92|GJE1
     1  MSLNYIKNFY EGCVKPPTVI GQFHTLFFGS IRIFFLGVLG FAVYGNEALH FICDPDKREV
    61  NLFCYNQFRP ITPQVSFSAL QLVIVLVPGA LFHLYAACKS INQECILQKP IYTIIYILSV
   121  LLRISLAAIA FWLQIYLFGF QVKSLYLCDA RSLGENMIIR CMVPEHFEKT IFLIAINTFT
   181  TITILLFVAE IFEIIFRRLY FPFRQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GJE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
0 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM
  • blood vessel: 0 nTPM

Single-cell type

  • cardiomyocytes: 0.2 nCPM
  • pericytes: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • medulla oblongata: 0.7 nTPM
  • spinal cord: 0.4 nTPM
  • white matter: 0.4 nTPM
  • cerebellum: 0.3 nTPM
  • cerebral cortex: 0.3 nTPM
  • midbrain: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.23
gnomAD pLI
0.11
gnomAD missense Z
0.58

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GJE1 as an antibody target. Whether an autoantibody or antibody against GJE1 could matter depends on whether native GJE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GJE1 is annotated at the cell surface, where native GJE1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GJE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GJE1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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