Seroatlas · Human Serome Atlas

GJD3

Gap junction delta-3 protein

Also known as: Cx30.2, CX31.9, CXD3_HUMAN, GJA11, GJC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N144
Gene: GJD3
Ensembl: ENSG00000183153
Chromosome: 17
Canonical length: 294 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

This gene is a member of the large family of connexins that are required for the formation of gap junctions. Six connexin monomers form a hemichannel, or connexon, on the cell surface. This connexon can interact with a connexon from a neighboring cell, thus forming a channel linking the cytoplasm of the 2 cells. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

294 residues, UniProt reviewed canonical sequence.

>Q8N144|GJD3
     1  MGEWAFLGSL LDAVQLQSPL VGRLWLVVML IFRILVLATV GGAVFEDEQE EFVCNTLQPG
    61  CRQTCYDRAF PVSHYRFWLF HILLLSAPPV LFVVYSMHRA GKEAGGAEAA AQCAPGLPEA
   121  QCAPCALRAR RARRCYLLSV ALRLLAELTF LGGQALLYGF RVAPHFACAG PPCPHTVDCF
   181  VSRPTEKTVF VLFYFAVGLL SALLSVAELG HLLWKGRPRA GERDNRCNRA HEEAQKLLPP
   241  PPPPPPPPAL PSRRPGPEPC APPAYAHPAP ASLRECGSGR GKASPATGRR DLAI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GJD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 7.6 nTPM

Expression across tissuesHPA

Tissue

spleen: 7.6 nTPM
thyroid gland: 4 nTPM
lung: 3.6 nTPM
prostate: 3.6 nTPM
heart muscle: 3.3 nTPM
esophagus: 3.2 nTPM

Single-cell type

lymphatic endothelial cells: 10 nCPM
epicardial cells: 4.5 nCPM
pericytes: 3.3 nCPM
endometrial luminal cells: 2.5 nCPM
vascular endothelial cells: 2.4 nCPM
endometrial stromal cells: 2.2 nCPM

Immune cell

NK-cell: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

hypothalamus: 2.1 nTPM
pons: 1.5 nTPM
midbrain: 1.2 nTPM
medulla oblongata: 1.1 nTPM
basal ganglia: 1 nTPM
thalamus: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.9
gnomAD pLI: 0
gnomAD missense Z: 0.76
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell communication
cell-cell signaling
gap junction assembly
negative regulation of heart rate
response to glucose
negative regulation of cardiac conduction

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GJD3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TJP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GJD3 as an antibody target. Whether an autoantibody or antibody against GJD3 could matter depends on whether native GJD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GJD3 is annotated at the cell surface, where native GJD3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GJD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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