Seroatlas · Human Serome Atlas

GJB7

Gap junction beta-7 protein

Also known as: bA136M9.1, CX25, CXB7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PEY0
Gene: GJB7
Ensembl: ENSG00000164411
Chromosome: 6
Canonical length: 223 aa
Protein class: Predicted membrane proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Connexins, such as GJB7, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

223 residues, UniProt reviewed canonical sequence.

>Q6PEY0|GJB7
     1  MSWMFLRDLL SGVNKYSTGT GWIWLAVVFV FRLLVYMVAA EHVWKDEQKE FECNSRQPGC
    61  KNVCFDDFFP ISQVRLWALQ LIMVSTPSLL VVLHVAYHEG REKRHRKKLY VSPGTMDGGL
   121  WYAYLISLIV KTGFEIGFLV LFYKLYDGFS VPYLIKCDLK PCPNTVDCFI SKPTEKTIFI
   181  LFLVITSCLC IVLNFIELSF LVLKCFIKCC LQKYLKKPQV LSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GJB7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 6.6 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 6.6 nTPM
pituitary gland: 5 nTPM
placenta: 2.5 nTPM
testis: 0.9 nTPM
lung: 0.6 nTPM
stomach: 0.3 nTPM

Single-cell type

gonadotrophs: 83 nCPM
cardiomyocytes: 33 nCPM
epididymal efferent duct ciliated cells: 30 nCPM
cytotrophoblasts: 25 nCPM
fallopian tube ciliated cells: 23 nCPM
endometrial ciliated cells: 21 nCPM

Immune cell

basophil: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 3.6 nTPM
cerebral cortex: 2.9 nTPM
medulla oblongata: 2.7 nTPM
pons: 2.7 nTPM
white matter: 2.1 nTPM
amygdala: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0
gnomAD missense Z: -0.37
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

gap junction channel activity

Cellular components

connexin complex

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GJB7 as an antibody target. Whether an autoantibody or antibody against GJB7 could matter depends on whether native GJB7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GJB7 is annotated at the cell surface, where native GJB7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GJB7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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