Seroatlas · Human Serome Atlas

GJB5

Gap junction beta-5 protein

Also known as: CX31.1, CXB5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95377
Gene: GJB5
Ensembl: ENSG00000189280
Chromosome: 1
Canonical length: 273 aa
Protein class: Cancer-related genes, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the beta-type (group I) connexin family. The encoded protein is a gap junction protein involved in intercellular communication related to epidermal differentiation and environmental sensing. This gene has been linked to non-small cell lung cancer. [provided by RefSeq, Nov 2012]

Canonical amino-acid sequenceUniProt

273 residues, UniProt reviewed canonical sequence.

>O95377|GJB5
     1  MNWSIFEGLL SGVNKYSTAF GRIWLSLVFI FRVLVYLVTA ERVWSDDHKD FDCNTRQPGC
    61  SNVCFDEFFP VSHVRLWALQ LILVTCPSLL VVMHVAYREV QEKRHREAHG ENSGRLYLNP
   121  GKKRGGLWWT YVCSLVFKAS VDIAFLYVFH SFYPKYILPP VVKCHADPCP NIVDCFISKP
   181  SEKNIFTLFM VATAAICILL NLVELIYLVS KRCHECLAAR KAQAMCTGHH PHGTTSSCKQ
   241  DDLLSGDLIF LGSDSHPPLL PDRPRDHVKK TIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GJB5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 98 nTPM

Expression across tissuesHPA

Tissue

esophagus: 98 nTPM
skin: 91 nTPM
vagina: 34 nTPM
cervix: 21 nTPM
salivary gland: 13 nTPM
tonsil: 12 nTPM

Single-cell type

esophageal apical cells: 422 nCPM
esophageal suprabasal cells: 302 nCPM
esophageal basal cells: 146 nCPM
suprabasal keratinocytes: 102 nCPM
ocular epithelial cells: 58 nCPM
basal keratinocytes: 52 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hippocampal formation: 3.1 nTPM
cerebral cortex: 2.9 nTPM
amygdala: 2.3 nTPM
white matter: 1.9 nTPM
basal ganglia: 1.5 nTPM
thalamus: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.83
gnomAD pLI: 0
gnomAD missense Z: 0.05
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

gap junction channel activity

Cellular components

connexin complex

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GJB5 as an antibody target. Whether an autoantibody or antibody against GJB5 could matter depends on whether native GJB5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GJB5 is annotated at the cell surface, where native GJB5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GJB5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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