Seroatlas · Human Serome Atlas

GJA9

Gap junction alpha-9 protein

Also known as: CX58, CX59, CXA9_HUMAN, GJA10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P57773
Gene: GJA9
Ensembl: ENSG00000131233
Chromosome: 1
Canonical length: 515 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Connexins, such as GJA9, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

515 residues, UniProt reviewed canonical sequence.

>P57773|GJA9
     1  MGDWNLLGDT LEEVHIHSTM IGKIWLTILF IFRMLVLGVA AEDVWNDEQS GFICNTEQPG
    61  CRNVCYDQAF PISLIRYWVL QVIFVSSPSL VYMGHALYRL RVLEEERQRM KAQLRVELEE
   121  VEFEMPRDRR RLEQELCQLE KRKLNKAPLR GTLLCTYVIH IFTRSVVEVG FMIGQYLLYG
   181  FHLEPLFKCH GHPCPNIIDC FVSRPTEKTI FLLFMQSIAT ISLFLNILEI FHLGFKKIKR
   241  GLWGKYKLKK EHNEFHANKA KQNVAKYQST SANSLKRLPS APDYNLLVEK QTHTAVYPSL
   301  NSSSVFQPNP DNHSVNDEKC ILDEQETVLS NEISTLSTSC SHFQHISSNN NKDTHKIFGK
   361  ELNGNQLMEK RETEGKDSKR NYYSRGHRSI PGVAIDGENN MRQSPQTVFS LPANCDWKPR
   421  WLRATWGSST EHENRGSPPK GNLKGQFRKG TVRTLPPSQG DSQSLDIPNT ADSLGGLSFE
   481  PGLVRTCNNP VCPPNHVVSL TNNLIGRRVP TDLQI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GJA9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 0.5 nTPM

Expression across tissuesHPA

Tissue

testis: 0.5 nTPM
esophagus: 0.4 nTPM
heart muscle: 0.4 nTPM
midbrain: 0.4 nTPM
retina: 0.4 nTPM
skin: 0.4 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

naive B-cell: 0.3 nTPM
intermediate monocyte: 0.2 nTPM
neutrophil: 0.2 nTPM
T-reg: 0.2 nTPM
classical monocyte: 0.1 nTPM
memory B-cell: 0.1 nTPM

Brain region

midbrain: 7.4 nTPM
medulla oblongata: 6.5 nTPM
pons: 4.9 nTPM
white matter: 4.8 nTPM
cerebral cortex: 4.4 nTPM
basal ganglia: 4.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.56
gnomAD pLI: 0
gnomAD missense Z: 0.94
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GJA9 as an antibody target. Whether an autoantibody or antibody against GJA9 could matter depends on whether native GJA9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GJA9 is annotated at the cell surface, where native GJA9 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GJA9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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