Seroatlas · Human Serome Atlas

GJA10

Gap junction alpha-10 protein

Also known as: CX62, CXA10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q969M2
Gene: GJA10
Ensembl: ENSG00000135355
Chromosome: 6
Canonical length: 543 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Connexins, such as GJA10, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

543 residues, UniProt reviewed canonical sequence.

>Q969M2|GJA10
     1  MGDWNLLGGI LEEVHSHSTI VGKIWLTILF IFRMLVLRVA AEDVWDDEQS AFACNTRQPG
    61  CNNICYDDAF PISLIRFWVL QIIFVSSPSL VYMGHALYRL RAFEKDRQRK KSHLRAQMEN
   121  PDLDLEEQQR IDRELRRLEE QKRIHKVPLK GCLLRTYVLH ILTRSVLEVG FMIGQYILYG
   181  FQMHPLYKCT QPPCPNAVDC FVSRPTEKTI FMLFMHSIAA ISLLLNILEI FHLGIRKIMR
   241  TLYKKSSSEG IEDETGPPFH LKKYSVAQQC MICSSLPERI SPLQANNQQQ VIRVNVPKSK
   301  TMWQIPQPRQ LEVDPSNGKK DWSEKDQHSG QLHVHSPCPW AGSAGNQHLG QQSDHSSFGL
   361  QNTMSQSWLG TTTAPRNCPS FAVGTWEQSQ DPEPSGEPLT DLHSHCRDSE GSMRESGVWI
   421  DRSRPGSRKA SFLSRLLSEK RHLHSDSGSS GSRNSSCLDF PHWENSPSPL PSVTGHRTSM
   481  VRQAALPIME LSQELFHSGC FLFPFFLPGV CMYVCVDREA DGGGDYLWRD KIIHSIHSVK
   541  FNS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GJA10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 0.7 nTPM

Expression across tissuesHPA

Tissue

retina: 0.7 nTPM
testis: 0.3 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

astrocytes: 0.1 nCPM
brain excitatory neurons: 0.1 nCPM
brain inhibitory neurons: 0.1 nCPM
distal convoluted tubule cells: 0.1 nCPM
loop of henle epithelial cells: 0.1 nCPM
oligodendrocyte progenitor cells: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.42
gnomAD pLI: 0
gnomAD missense Z: -0.72
DepMap mean gene effect: -0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

gap junction channel activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GJA10 as an antibody target. Whether an autoantibody or antibody against GJA10 could matter depends on whether native GJA10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GJA10 is annotated at the cell surface, where native GJA10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GJA10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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