Seroatlas · Human Serome Atlas

GIPC2

PDZ domain-containing protein GIPC2

Also known as: FLJ20075, GIPC2_HUMAN, SEMCAP-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TF65
Gene: GIPC2
Ensembl: ENSG00000137960
Chromosome: 1
Canonical length: 315 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables identical protein binding activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

315 residues, UniProt reviewed canonical sequence.

>Q8TF65|GIPC2
     1  MPLKLRGKKK AKSKETAGLV EGEPTGAGGG SLSASRAPAR RLVFHAQLAH GSATGRVEGF
    61  SSIQELYAQI AGAFEISPSE ILYCTLNTPK IDMERLLGGQ LGLEDFIFAH VKGIEKEVNV
   121  YKSEDSLGLT ITDNGVGYAF IKRIKDGGVI DSVKTICVGD HIESINGENI VGWRHYDVAK
   181  KLKELKKEEL FTMKLIEPKK AFEIELRSKA GKSSGEKIGC GRATLRLRSK GPATVEEMPS
   241  ETKAKAIEKI DDVLELYMGI RDIDLATTMF EAGKDKVNPD EFAVALDETL GDFAFPDEFV
   301  FDVWGVIGDA KRRGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GIPC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

kidney: 39 nTPM
small intestine: 36 nTPM
duodenum: 36 nTPM
spleen: 26 nTPM
adrenal gland: 23 nTPM
liver: 17 nTPM

Single-cell type

adrenal cortex cells: 303 nCPM
enterocytes: 228 nCPM
proximal tubule cells: 202 nCPM
epididymal efferent duct absorptive cells: 157 nCPM
pancreatic acinar cells: 140 nCPM
lymphatic endothelial cells: 132 nCPM

Immune cell

MAIT T-cell: 0.3 nTPM
naive CD4 T-cell: 0.2 nTPM
memory CD4 T-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

choroid plexus: 0.9 nTPM
amygdala: 0.8 nTPM
cerebral cortex: 0.8 nTPM
hippocampal formation: 0.8 nTPM
thalamus: 0.8 nTPM
basal ganglia: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.59
gnomAD pLI: 0
gnomAD missense Z: -0.27
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

identical protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Cytoplasm

InteractionsUniProt · HPA

Protein binding partners of GIPC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SEMA5A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GIPC2 as an antibody target. Whether an autoantibody or antibody against GIPC2 could matter depends on whether native GIPC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GIPC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GIPC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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