Seroatlas · Human Serome Atlas

GINM1

Glycoprotein integral membrane protein 1

Also known as: C6orf72, dJ12G14.2, GINM1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NU53
Gene: GINM1
Ensembl: ENSG00000055211
Chromosome: 6
Canonical length: 330 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoli fibrillar center,Plasma membrane

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

330 residues, UniProt reviewed canonical sequence.

>Q9NU53|GINM1
     1  MEGAPPGSLA LRLLLFVALP ASGWLTTGAP EPPPLSGAPQ DGIRINVTTL KDDGDISKQQ
    61  VVLNITYESG QVYVNDLPVN SGVTRISCQT LIVKNENLEN LEEKEYFGIV SVRILVHEWP
   121  MTSGSSLQLI VIQEEVVEID GKQVQQKDVT EIDILVKNRG VLRHSNYTLP LEESMLYSIS
   181  RDSDILFTLP NLSKKESVSS LQTTSQYLIR NVETTVDEDV LPGKLPETPL RAEPPSSYKV
   241  MCQWMEKFRK DLCRFWSNVF PVFFQFLNIM VVGITGAAVV ITILKVFFPV SEYKGILQLD
   301  KVDVIPVTAI NLYPDGPEKR AENLEDKTCI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GINM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 86 nTPM

Expression across tissuesHPA

Tissue

kidney: 86 nTPM
thyroid gland: 69 nTPM
blood vessel: 60 nTPM
placenta: 59 nTPM
ovary: 58 nTPM
heart muscle: 55 nTPM

Single-cell type

late spermatids: 698 nCPM
late primary spermatocytes: 249 nCPM
syncytiotrophoblasts: 177 nCPM
early spermatids: 169 nCPM
decidual stromal cells: 143 nCPM
early primary spermatocytes: 136 nCPM

Immune cell

neutrophil: 32 nTPM
eosinophil: 25 nTPM
non-classical monocyte: 24 nTPM
memory B-cell: 23 nTPM
basophil: 21 nTPM
classical monocyte: 19 nTPM

Brain region

choroid plexus: 56 nTPM
white matter: 54 nTPM
cerebellum: 45 nTPM
medulla oblongata: 40 nTPM
basal ganglia: 39 nTPM
spinal cord: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
gnomAD missense Z: 1.05
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Glycoprotein integral membrane protein 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GINM1 as an antibody target. Whether an autoantibody or antibody against GINM1 could matter depends on whether native GINM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GINM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GINM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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