GIG44
Putative insulin-like growth factor 2-associated protein
Also known as: IG2R_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for GIG44 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
113 residues, UniProt reviewed canonical sequence.
>P09565|GIG44
1 MTPGVVHASP PQSQRVPRQA PCEWAIRNIG QKPKEPNCHN CGTHIGLRSK TLRGTPNYLP
61 IRQDTHPPSV IFCLAGVGVP GGTCRPAPCV PRFAALPWAT NHPGPGCLSD LRALocalizationUniProt · AlphaFold · HPA
Whether an antibody against GIG44 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.71
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GIG44 as an antibody target. Whether an autoantibody or antibody against GIG44 could matter depends on whether native GIG44 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GIG44 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label GIG44 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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