Seroatlas · Human Serome Atlas

GHSR

Growth hormone secretagogue receptor type 1

Also known as: GHSR_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92847
Gene
GHSR
Ensembl
ENSG00000121853
Chromosome
3
Canonical length
366 aa
Protein class
Disease related genes, G-protein coupled receptors, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.[provided by RefSeq, Apr 2010]

Canonical amino-acid sequenceUniProt

366 residues, UniProt reviewed canonical sequence.

>Q92847|GHSR
     1  MWNATPSEEP GFNLTLADLD WDASPGNDSL GDELLQLFPA PLLAGVTATC VALFVVGIAG
    61  NLLTMLVVSR FRELRTTTNL YLSSMAFSDL LIFLCMPLDL VRLWQYRPWN FGDLLCKLFQ
   121  FVSESCTYAT VLTITALSVE RYFAICFPLR AKVVVTKGRV KLVIFVIWAV AFCSAGPIFV
   181  LVGVEHENGT DPWDTNECRP TEFAVRSGLL TVMVWVSSIF FFLPVFCLTV LYSLIGRKLW
   241  RRRRGDAVVG ASLRDQNHKQ TVKMLAVVVF AFILCWLPFH VGRYLFSKSF EPGSLEIAQI
   301  SQYCNLVSFV LFYLSAAINP ILYNIMSKKY RVAVFRLLGF EPFSQRKLST LKDESSRAWT
   361  ESSINT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GHSR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
3.5 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 3.5 nTPM
  • hypothalamus: 0.6 nTPM
  • adrenal gland: 0.2 nTPM
  • appendix: 0.1 nTPM
  • basal ganglia: 0.1 nTPM
  • bone marrow: 0.1 nTPM

Single-cell type

  • somatotrophs: 19 nCPM
  • corticotrophs: 18 nCPM
  • lactotrophs: 5.8 nCPM
  • thyrotrophs: 4.8 nCPM
  • pancreatic islet cells: 3.6 nCPM
  • other brain neurons: 2.2 nCPM

Immune cell

  • NK-cell: 0.5 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • hypothalamus: 33 nTPM
  • hippocampal formation: 8.1 nTPM
  • medulla oblongata: 2.8 nTPM
  • pons: 1.8 nTPM
  • amygdala: 1.5 nTPM
  • cerebral cortex: 1.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GHSR.

Disease | AllUniProt

Conditions GHSR is implicated in, by any mechanism.

  • Growth hormone deficiency, isolated partial (GHDP) MIM:615925

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 289 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Short stature due to growth hormone secretagogue receptor deficiency

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.01
gnomAD pLI
0.01
gnomAD missense Z
0.19
DepMap mean gene effect
0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GHSR as an antibody target. Whether an autoantibody or antibody against GHSR could matter depends on whether native GHSR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GHSR is annotated at the cell surface, where native GHSR is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GHSR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GHSR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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