Seroatlas · Human Serome Atlas

GHDC

GH3 domain-containing protein

Also known as: GHDC_HUMAN, LGP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N2G8
Gene: GHDC
Ensembl: ENSG00000167925
Chromosome: 17
Canonical length: 530 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Predicted to enable acid-amino acid ligase activity. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

530 residues, UniProt reviewed canonical sequence.

>Q8N2G8|GHDC
     1  MLLWPLLLLL LLLPTLALLR QQRSQDARLS WLAGLQHRVA WGALVWAATW QRRRLEQSTL
    61  HVHQSQQQAL RWCLQGAQRP HCSLRRSTDI STFRNHLPLT KASQTQQEDS GEQPLPPTSN
   121  QDLGEASLQA TLLGLAALNK AYPEVLAQGR TARVTLTSPW PRPLPWPGNT LGQVGTPGTK
   181  DPRALLLDAL RSPGLRALEA GTAVELLDVF LGLETDGEEL AGAIAAGNPG APLRERAAEL
   241  REALEQGPRG LALRLWPKLQ VVVTLDAGGQ AEAVAALGAL WCQGLAFFSP AYAASGGVLG
   301  LNLQPEQPHG LYLLPPGAPF IELLPVKEGT QEEAASTLLL AEAQQGKEYE LVLTDRASLT
   361  RCRLGDVVRV VGAYNQCPVV RFICRLDQTL SVRGEDIGED LFSEALGRAV GQWAGAKLLD
   421  HGCVESSILD SSAGSAPHYE VFVALRGLRN LSEENRDKLD HCLQEASPRY KSLRFWGSVG
   481  PARVHLVGQG AFRALRAALA ACPSSPFPPA MPRVLRHRHL AQCLQERVVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GHDC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 32 nTPM
spleen: 31 nTPM
thyroid gland: 26 nTPM
pancreas: 25 nTPM
kidney: 23 nTPM
salivary gland: 23 nTPM

Single-cell type

hofbauer cells: 42 nCPM
kupffer cells: 35 nCPM
prostatic glandular cells: 29 nCPM
lacrimal acinar cells: 27 nCPM
decidual stromal cells: 26 nCPM
salivary acinar cells: 25 nCPM

Immune cell

naive B-cell: 4.1 nTPM
non-classical monocyte: 4.1 nTPM
classical monocyte: 3.2 nTPM
intermediate monocyte: 3 nTPM
myeloid DC: 2.7 nTPM
total PBMC: 2.6 nTPM

Brain region

medulla oblongata: 25 nTPM
pons: 21 nTPM
white matter: 20 nTPM
midbrain: 19 nTPM
hypothalamus: 19 nTPM
thalamus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: 0.88
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

acid-amino acid ligase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

GH3 family
GH3, middle domain
GH3, C-terminal domain
GH3 domain-containing protein, N-terminal domain
GH3 family central domain
GH3 family C-terminal domain
Vertebrate GH3, N-terminal domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GHDC as an antibody target. Whether an autoantibody or antibody against GHDC could matter depends on whether native GHDC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GHDC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GHDC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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