Seroatlas · Human Serome Atlas

GGTA1

Inactive N-acetyllactosaminide alpha-1,3-galactosyltransferase

Also known as: GGTA, GGTA1_HUMAN, GGTA1P, GLYT2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q4G0N0
Gene
GGTA1
Ensembl
ENSG00000204136
Chromosome
9
Canonical length
100 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

Alpha-1,3-galactosyltransferase (GGTA1) is an enzyme present in most mammals except man, apes, and Old World monkeys. This gene is thought to encode a truncated, non-enzymatic form of the GGTA1 protein that lacks the C-terminal catalytic domain. Aberrant expression of the GGTA1 protein in man can lead to autoimmune diseases and sometimes germ cell tumors. [provided by RefSeq, May 2020]

Canonical amino-acid sequenceUniProt

100 residues, UniProt reviewed canonical sequence.

>Q4G0N0|GGTA1
     1  MNVKGKVILS MLVVSTVIIV FWEFINSTEG SFLWIYHSKN PEVDDSSAQK GWWFLSWFNN
    61  GIHNYQQGEE DIDKEKGREE TKGRKMTQQS FGYGTGLIQT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GGTA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
125 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 125 nTPM
  • blood vessel: 88 nTPM
  • bone marrow: 64 nTPM
  • basal ganglia: 47 nTPM
  • placenta: 39 nTPM
  • spleen: 38 nTPM

Single-cell type

  • hofbauer cells: 544 nCPM
  • platelets: 425 nCPM
  • kupffer cells: 385 nCPM
  • salivary acinar cells: 378 nCPM
  • cdc: 207 nCPM
  • macrophages: 200 nCPM

Immune cell

  • plasmacytoid DC: 28 nTPM
  • classical monocyte: 23 nTPM
  • intermediate monocyte: 18 nTPM
  • myeloid DC: 13 nTPM
  • total PBMC: 7.2 nTPM
  • neutrophil: 1.2 nTPM

Brain region

  • basal ganglia: 19 nTPM
  • hippocampal formation: 13 nTPM
  • thalamus: 12 nTPM
  • amygdala: 11 nTPM
  • cerebral cortex: 11 nTPM
  • hypothalamus: 11 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GGTA1 as an antibody target. Whether an autoantibody or antibody against GGTA1 could matter depends on whether native GGTA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GGTA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

  • Aberrant expression of the GGTA1 protein in man can lead to autoimmune diseases and sometimes germ cell tumors.

Canonical record: https://seroatlas.com/gene/GGTA1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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