Seroatlas · Human Serome Atlas

GGCT

Gamma-glutamylcyclotransferase

Also known as: C7orf24, CRF21, GCTG, Ggc, GGCT_HUMAN, MGC3077

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75223
Gene
GGCT
Ensembl
ENSG00000006625
Chromosome
7
Canonical length
188 aa
Protein class
Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

188 residues, UniProt reviewed canonical sequence.

>O75223|GGCT
     1  MANSGCKDVT GPDEESFLYF AYGSNLLTER IHLRNPSAAF FCVARLQDFK LDFGNSQGKT
    61  SQTWHGGIAT IFQSPGDEVW GVVWKMNKSN LNSLDEQEGV KSGMYVVIEV KVATQEGKEI
   121  TCRSYLMTNY ESAPPSPQYK KIICMGAKEN GLPLEYQEKL KAIEPNDYTG KVSEEIEDII
   181  KKGETQTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GGCT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
99 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 99 nTPM
  • adipose tissue: 58 nTPM
  • skin: 53 nTPM
  • esophagus: 51 nTPM
  • breast: 45 nTPM
  • parathyroid gland: 41 nTPM

Single-cell type

  • cytotrophoblasts: 502 nCPM
  • esophageal suprabasal cells: 387 nCPM
  • migrating cytotrophoblasts: 357 nCPM
  • esophageal apical cells: 349 nCPM
  • epididymal principal cells: 341 nCPM
  • esophageal basal cells: 303 nCPM

Immune cell

  • myeloid DC: 34 nTPM
  • plasmacytoid DC: 30 nTPM
  • T-reg: 26 nTPM
  • NK-cell: 25 nTPM
  • memory B-cell: 23 nTPM
  • intermediate monocyte: 21 nTPM

Brain region

  • basal ganglia: 15 nTPM
  • thalamus: 14 nTPM
  • cerebral cortex: 13 nTPM
  • choroid plexus: 13 nTPM
  • hippocampal formation: 10 nTPM
  • hypothalamus: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.34
gnomAD pLI
0
gnomAD missense Z
0.29
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GGCT as an antibody target. Whether an autoantibody or antibody against GGCT could matter depends on whether native GGCT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GGCT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GGCT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GGCT. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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