Seroatlas · Human Serome Atlas

GFY

Golgi-associated olfactory signaling regulator

Also known as: GFY_HUMAN, Goofy

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: I3L273
Gene: GFY
Ensembl: ENSG00000261949
Chromosome: 19
Canonical length: 518 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in sensory perception of smell. Predicted to act upstream of or within non-motile cilium assembly and protein localization to non-motile cilium. Predicted to be located in Golgi membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

518 residues, UniProt reviewed canonical sequence.

>I3L273|GFY
     1  MKSFSRILFL VFLLAGLRSK AAPSAPLPLG CGFPDMAHPS ETSPLKGASE NSKRDRLNPE
    61  FPGTPYPEPS KLPHTVSLET FPLDFTEPLN PDLRETPHPE SPETPKADSL TTSISESLDM
   121  PKTNLSKMAH PESSETPTPG PTEMPHPGSP ETPKPNFSKT SRPEFPETPN TDLMQTTPQE
   181  SPEILQLNAT EVSQAELPET SNTNPTKTPD PKSPEKHDLN STETPNSEFL QALHPDPSKT
   241  PHPESHVTHN PSPTEISQTE FPTTYYQNAT DVPRTSDPQI STSLYPETPV PFKDDATALN
   301  ELSLNPKPGT PAAIQPDSPK LPTSDSPGMV ELKAPQNSGP KESNVPPPSA RIAGPPALPG
   361  RPSQLAPATL RAPQRHSRGE GVNTIIVVER VKETGVTLVG RPRGAAGGAL CLFFAGTALL
   421  IGIFVLLWCL YRRAARQRPF AHHRLPDDGD EPVLHLDAPK DPYDLYFYAP DTWVPSHIAT
   481  KQPPPTPPLP PKLPPPPRGG RPQRLEALSP ATLPNNFV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GFY can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 1.3 nTPM

Expression across tissuesHPA

Tissue

testis: 1.3 nTPM
cerebellum: 0.5 nTPM
retina: 0.5 nTPM
cerebral cortex: 0.4 nTPM
amygdala: 0.2 nTPM
hippocampal formation: 0.1 nTPM

Single-cell type

oocytes: 18 nCPM
late primary spermatocytes: 1.8 nCPM
breast myoepithelial cells: 0.9 nCPM
late spermatids: 0.7 nCPM
early primary spermatocytes: 0.5 nCPM
retinal bipolar cells: 0.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 2.1 nTPM
cerebral cortex: 0.9 nTPM
pons: 0.8 nTPM
medulla oblongata: 0.5 nTPM
basal ganglia: 0.4 nTPM
hippocampal formation: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.57
gnomAD pLI: 0.56
gnomAD missense Z: 1.61
DepMap mean gene effect: -0.1
DepMap dependency class: selective

OntologyGO

Biological processes

Cellular components

Golgi membrane

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GFY as an antibody target. Whether an autoantibody or antibody against GFY could matter depends on whether native GFY is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GFY is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GFY as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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