Seroatlas · Human Serome Atlas

GDPGP1

GDP-D-glucose phosphorylase 1

Also known as: C15orf58, GDPP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZNW5
Gene: GDPGP1
Ensembl: ENSG00000183208
Chromosome: 15
Canonical length: 385 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables GDP-D-glucose phosphorylase activity. Involved in glucose metabolic process. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

385 residues, UniProt reviewed canonical sequence.

>Q6ZNW5|GDPGP1
     1  MALPHDSNET SYLLPPNNED WGRQTIPDFV YGQKDLMAEG IQWPRNAPGI PDALPQSPFD
    61  AALCSAWKQR VELGLFRYRL RELQTQILPG AVGFVAQLNV ERGVQRRPPQ TIKSVRQAFD
   121  PVQFNFNKIR PGEVLFRLHR EPDLPGTLLQ EDILVVINVS PLEWGHVLLV PEPARQLPQR
   181  LLPGALRAGI EAVLLSLHPG FRVGFNSLGG LASVNHLHLH GYYLAHRLPV EQAPSEPLDP
   241  GGHLHLLQDL PAPGFLFYTR GPGPDLESLI SRVCRATDYL TDHEIAHNLF VTRGAPPGKT
   301  SPSSALTGVR VILWARKSSF GIKDGEAFNV ALCELAGHLP VKTSQDFSSL TEAAAVALIQ
   361  DCRLPPSQAE DVQAALVALM SQEEQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GDPGP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 6.3 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 6.3 nTPM
liver: 1.8 nTPM
heart muscle: 1.4 nTPM
duodenum: 1.3 nTPM
kidney: 1.2 nTPM
pituitary gland: 1.2 nTPM

Single-cell type

cardiomyocytes: 4.6 nCPM
mesothelial cells: 1.6 nCPM
adipocytes: 0.8 nCPM
thymocytes: 0.8 nCPM
pericytes: 0.4 nCPM
salivary ionocytes: 0.4 nCPM

Immune cell

basophil: 2.4 nTPM
NK-cell: 2.3 nTPM
memory CD8 T-cell: 2.2 nTPM
naive B-cell: 2.2 nTPM
gdT-cell: 2.1 nTPM
intermediate monocyte: 2.1 nTPM

Brain region

pons: 11 nTPM
cerebellum: 11 nTPM
cerebral cortex: 11 nTPM
choroid plexus: 11 nTPM
white matter: 11 nTPM
basal ganglia: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.84
gnomAD pLI: 0
gnomAD missense Z: 0.18
DepMap mean gene effect: 0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

guanyl-nucleotide exchange factor activity
hydrolase activity
nucleotide binding
GDP-D-glucose phosphorylase activity

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

GDP-L-galactose/GDP-D-glucose phosphorylase
GDPGP1-like, C-terminal domain
GDPGP1-like, N-terminal domain
GDPGP1-like, C-terminal domain
GDPGP1-like, N-terminal domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GDPGP1 as an antibody target. Whether an autoantibody or antibody against GDPGP1 could matter depends on whether native GDPGP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GDPGP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GDPGP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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