Seroatlas · Human Serome Atlas

GDF5-AS1

Protein GDF5-AS1, mitochondrial

Also known as: GDAS1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5U4N7
Gene: GDF5-AS1
Canonical length: 250 aa

OverviewNCBI Gene

No narrative summary is available for GDF5-AS1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

250 residues, UniProt reviewed canonical sequence.

>Q5U4N7|GDF5-AS1
     1  MIQSSQPMSL KLTCSAFRLQ RALRFLLGRL PWRVASGARR FRRWLNRYSY TVLSSWPERA
    61  LISLKNRSRF LVRPNTRNRA FSWTCRAARS KPRPRRSTAL PRSQASSSRH SWAEFLKFRK
   121  SFQMSNTSQP DPSRPGTERT SSKEAGCRPL GQLDSFSWAA RPPPGAAGLA VSEGFFRKIR
   181  SSAPSSPSFS RALMSNTYLC FLTTGPRSSR ENTQKSFPAT SPREPVTSRL RGKAPALSPS
   241  RELSFTSAPF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GDF5-AS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7

OntologyGO

Cellular components

mitochondrion

Protein domainsUniProt · Pfam · InterPro

Protein GDF5OS, mitochondrial

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GDF5-AS1 as an antibody target. Whether an autoantibody or antibody against GDF5-AS1 could matter depends on whether native GDF5-AS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GDF5-AS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GDF5-AS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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