Seroatlas · Human Serome Atlas

GCSAML

Germinal center-associated signaling and motility-like protein

Also known as: C1orf150, FLJ44728, GSAML_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5JQS6
Gene: GCSAML
Ensembl: ENSG00000169224
Chromosome: 1
Canonical length: 135 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes a protein thought to be a signaling molecule associated with germinal centers, the sites of proliferation and differentiation of mature B lymphocytes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

135 residues, UniProt reviewed canonical sequence.

>Q5JQS6|GCSAML
     1  MGNYLLRKLS CLGENQKKPK KGNPDEERKR QEMTTFERKL QDQDKKSQEV SSTSNQENEN
    61  GSGSEEVCYT VINHIPHQRS SLSSNDDGYE NIDSLTRKVR QFRERSETEY ALLRTSVSRP
   121  CSCTHEHDYE VVFPH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GCSAML can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 5.1 nTPM

Expression across tissuesHPA

Tissue

prostate: 5.1 nTPM
cerebellum: 4.9 nTPM
testis: 3.2 nTPM
lung: 2 nTPM
bone marrow: 1.6 nTPM
duodenum: 1.4 nTPM

Single-cell type

mast cells: 229 nCPM
megakaryocytes: 118 nCPM
platelets: 83 nCPM
megakaryocyte progenitors: 66 nCPM
prostatic glandular cells: 57 nCPM
hematopoietic stem cells: 45 nCPM

Immune cell

basophil: 229 nTPM
total PBMC: 0.5 nTPM
naive CD4 T-cell: 0.3 nTPM
eosinophil: 0.2 nTPM
gdT-cell: 0.2 nTPM
intermediate monocyte: 0.2 nTPM

Brain region

cerebellum: 17 nTPM
pons: 5.8 nTPM
white matter: 5.3 nTPM
cerebral cortex: 4.5 nTPM
basal ganglia: 4.1 nTPM
choroid plexus: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0.12
gnomAD missense Z: -0.31
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GCSAML as an antibody target. Whether an autoantibody or antibody against GCSAML could matter depends on whether native GCSAML is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GCSAML is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GCSAML as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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