GCRG224
Putative gastric cancer-related gene 224 protein
Also known as: GC224_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for GCRG224 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
35 residues, UniProt reviewed canonical sequence.
>Q8WZA8|GCRG224
1 MIPGNPSPGA DLAVSKHFFS LSWFCGLLLL ESKQKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GCRG224 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.57
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GCRG224 as an antibody target. Whether an autoantibody or antibody against GCRG224 could matter depends on whether native GCRG224 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GCRG224 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label GCRG224 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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