GCM1

Protein identityUniProt · HPA

UniProt accession

Q9NP62

Gene

GCM1

Ensembl

ENSG00000137270

Chromosome

6

Canonical length

436 aa

Protein class

Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

436 residues, UniProt reviewed canonical sequence.

>Q9NP62|GCM1
     1  MEPDDFDSED KEILSWDIND VKLPQNVKKT DWFQEWPDSY AKHIYSSEDK NAQRHLSSWA
    61  MRNTNNHNSR ILKKSCLGVV VCGRDCLAEE GRKIYLRPAI CDKARQKQQR KRCPNCDGPL
   121  KLIPCRGHGG FPVTNFWRHD GRFIFFQSKG EHDHPKPETK LEAEARRAMK KVNTAPSSVS
   181  LSLKGSTETR SLPGETQSQG SLPLTWSFQE GVQLPGSYSG HLIANTPQQN SLNDCFSFSK
   241  SYGLGGITDL TDQTSTVDPM KLYEKRKLSS SRTYSSGDLL PPSASGVYSD HGDLQAWSKN
   301  AALGRNHLAD NCYSNYPFPL TSWPCSFSPS QNSSEPFYQQ LPLEPPAAKT GCPPLWPNPA
   361  GNLYEEKVHV DFNSYVQSPA YHSPQEDPFL FTYASHPHQQ YSLPSKSSKW DFEEEMTYLG
   421  LDHCNNDMLL NLCPLR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GCM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.57

Highest tissue expression

19 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.15

gnomAD pLI

1

gnomAD missense Z

1.44

DepMap mean gene effect

-0.02

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• anatomical structure morphogenesis
• astrocyte fate commitment
• branching involved in labyrinthine layer morphogenesis
• cell differentiation involved in embryonic placenta development
• gliogenesis
• positive regulation of DNA-templated transcription
• positive regulation of syncytium formation by plasma membrane fusion
• positive regulation of transcription by RNA polymerase II
• regulation of cell differentiation involved in embryonic placenta development
• regulation of DNA-templated transcription
• regulation of transcription by RNA polymerase II
• syncytium formation by plasma membrane fusion
• transcription by RNA polymerase II

Molecular functions

• DNA binding
• DNA-binding transcription activator activity, RNA polymerase II-specific
• DNA-binding transcription factor activity
• DNA-binding transcription factor activity, RNA polymerase II-specific
• histone deacetylase binding
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• sequence-specific double-stranded DNA binding
• zinc ion binding

Cellular components

• chromatin
• nucleus
• transcription regulator complex

Protein domainsUniProt · Pfam · InterPro

• Transcription regulator GCM domain
• GCM domain superfamily
• Chorion-specific transcription factor GCM
• GCM domain, large subdomain
• GCM, small domain
• GCM motif protein

KeywordsUniProt

• Developmental protein
• DNA-binding
• Metal-binding
• Nucleus
• Transcription
• Transcription regulation
• Ubl conjugation
• Zinc

InteractionsUniProt · HPA

Protein binding partners of GCM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FBXW2