GCKR

Protein identityUniProt · HPA

UniProt accession

Q14397

Gene

GCKR

Canonical length

625 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for GCKR in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

625 residues, UniProt reviewed canonical sequence.

>Q14397|GCKR
     1  MPGTKRFQHV IETPEPGKWE LSGYEAAVPI TEKSNPLTQD LDKADAENIV RLLGQCDAEI
    61  FQEEGQALST YQRLYSESIL TTMVQVAGKV QEVLKEPDGG LVVLSGGGTS GRMAFLMSVS
   121  FNQLMKGLGQ KPLYTYLIAG GDRSVVASRE GTEDSALHGI EELKKVAAGK KRVIVIGISV
   181  GLSAPFVAGQ MDCCMNNTAV FLPVLVGFNP VSMARNDPIE DWSSTFRQVA ERMQKMQEKQ
   241  KAFVLNPAIG PEGLSGSSRM KGGSATKILL ETLLLAAHKT VDQGIAASQR CLLEILRTFE
   301  RAHQVTYSQS PKIATLMKSV STSLEKKGHV YLVGWQTLGI IAIMDGVECI HTFGADFRDV
   361  RGFLIGDHSD MFNQKAELTN QGPQFTFSQE DFLTSILPSL TEIDTVVFIF TLDDNLTEVQ
   421  TIVEQVKEKT NHIQALAHST VGQTLPIPLK KLFPSIISIT WPLLFFEYEG NFIQKFQREL
   481  STKWVLNTVS TGAHVLLGKI LQNHMLDLRI SNSKLFWRAL AMLQRFSGQS KARCIESLLR
   541  AIHFPQPLSD DIRAAPISCH VQVAHEKEQV IPIALLSLLF RCSITEAQAH LAAAPSVCEA
   601  VRSALAGPGQ KRTADPLEIL EPDVQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GCKR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.21

Highest tissue expression

133 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.15

gnomAD pLI

0

gnomAD missense Z

-1.14

DepMap mean gene effect

0.03

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• intracellular glucose homeostasis
• negative regulation of glucokinase activity
• protein import into nucleus
• protein localization to nucleus
• response to fructose
• response to glucose
• triglyceride homeostasis
• urate metabolic process
• carbohydrate derivative metabolic process

Molecular functions

• fructose-6-phosphate binding
• glucose sensor activity
• kinase inhibitor activity

Cellular components

• cytoplasm
• cytosol
• mitochondrion
• nucleoplasm

Protein domainsUniProt · Pfam · InterPro

• SIS domain
• SIS domain superfamily
• Glucokinase regulatory protein, conserved site
• N-acetylmuramic acid 6-phosphate etherase/glucokinase regulatory protein
• Glucokinase regulatory protein, second SIS domain
• C-terminal lid domain of glucokinase regulatory protein
• Glucokinase regulatory protein, second SIS domain
• Glucokinase regulatory protein N-terminal SIS domain

KeywordsUniProt

• Carbohydrate metabolism
• Cytoplasm
• Mitochondrion
• Nucleus
• Repeat

InteractionsUniProt · HPA

Protein binding partners of GCKR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• GCK