GC

Protein identityUniProt · HPA

UniProt accession

P02774

Gene

GC

Ensembl

ENSG00000145321

Chromosome

4

Canonical length

474 aa

Protein class

Metabolic proteins, Plasma proteins, Predicted secreted proteins

Secretome location

Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

474 residues, UniProt reviewed canonical sequence.

>P02774|GC
     1  MKRVLVLLLA VAFGHALERG RDYEKNKVCK EFSHLGKEDF TSLSLVLYSR KFPSGTFEQV
    61  SQLVKEVVSL TEACCAEGAD PDCYDTRTSA LSAKSCESNS PFPVHPGTAE CCTKEGLERK
   121  LCMAALKHQP QEFPTYVEPT NDEICEAFRK DPKEYANQFM WEYSTNYGQA PLSLLVSYTK
   181  SYLSMVGSCC TSASPTVCFL KERLQLKHLS LLTTLSNRVC SQYAAYGEKK SRLSNLIKLA
   241  QKVPTADLED VLPLAEDITN ILSKCCESAS EDCMAKELPE HTVKLCDNLS TKNSKFEDCC
   301  QEKTAMDVFV CTYFMPAAQL PELPDVELPT NKDVCDPGNT KVMDKYTFEL SRRTHLPEVF
   361  LSKVLEPTLK SLGECCDVED STTCFNAKGP LLKKELSSFI DKGQELCADY SENTFTEYKK
   421  KLAERLKAKL PDATPTELAK LVNKHSDFAS NCCSINSPPL YCDSEIDAEL KNIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.29

Highest tissue expression

7,722 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GC.

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 72 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Chronic obstructive pulmonary disease

Disease | ImmuneIEDB

Conditions an epitope on GC was assayed in.

• rheumatoid arthritis B cell
• type 1 diabetes mellitus T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.08

gnomAD pLI

0

gnomAD missense Z

0.4

DepMap mean gene effect

0.06

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• response to nutrient levels
• vitamin D metabolic process
• vitamin transport

Molecular functions

• actin binding
• vitamin D binding
• vitamin transmembrane transporter activity
• calcidiol binding

Cellular components

• blood microparticle
• cytosol
• extracellular exosome
• extracellular region
• extracellular space
• lysosomal lumen

Protein domainsUniProt · Pfam · InterPro

• ALB/AFP/VDB
• Serum albumin, N-terminal
• Serum albumin, conserved site
• Serum albumin-like
• Serum albumin family
• Vitamin D-binding protein
• Vitamin D binding protein, domain III
• Vitamin D binding protein, domain III

KeywordsUniProt

• Actin-binding
• Disulfide bond
• Glycoprotein
• Repeat
• Secreted
• Signal
• Transport
• Vitamin D

InteractionsUniProt · HPA

Protein binding partners of GC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• LRP2