Seroatlas · Human Serome Atlas

GBGT1

Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1

Also known as: A3GALNT, FS, GBGT1_HUMAN, MGC44848, UDP-GalNAc

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N5D6
Gene
GBGT1
Ensembl
ENSG00000148288
Chromosome
9
Canonical length
347 aa
Protein class
Metabolic proteins, Predicted intracellular proteins
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes a glycosyltransferase that plays a role in the synthesis of Forssman glycolipid (FG), a member of the globoseries glycolipid family. Glycolipids such as FG form attachment sites for the binding of pathogens to cells; expression of this protein may determine host tropism to microorganisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Canonical amino-acid sequenceUniProt

347 residues, UniProt reviewed canonical sequence.

>Q8N5D6|GBGT1
     1  MHRRRLALGL GFCLLAGTSL SVLWVYLENW LPVSYVPYYL PCPEIFNMKL HYKREKPLQP
    61  VVWSQYPQPK LLEHRPTQLL TLTPWLAPIV SEGTFNPELL QHIYQPLNLT IGVTVFAVGK
   121  YTHFIQSFLE SAEEFFMRGY RVHYYIFTDN PAAVPGVPLG PHRLLSSIPI QGHSHWEETS
   181  MRRMETISQH IAKRAHREVD YLFCLDVDMV FRNPWGPETL GDLVAAIHPS YYAVPRQQFP
   241  YERRRVSTAF VADSEGDFYY GGAVFGGQVA RVYEFTRGCH MAILADKANG IMAAWREESH
   301  LNRHFISNKP SKVLSPEYLW DDRKPQPPSL KLIRFSTLDK DISCLRS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GBGT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • stomach: 24 nTPM
  • choroid plexus: 17 nTPM
  • ovary: 13 nTPM
  • placenta: 12 nTPM
  • adrenal gland: 12 nTPM
  • adipose tissue: 11 nTPM

Single-cell type

  • microglia: 16 nCPM
  • choroid plexus epithelial cells: 7.6 nCPM
  • astrocytes: 5.1 nCPM
  • other brain neurons: 4 nCPM
  • bergmann glia: 3.9 nCPM
  • brain excitatory neurons: 3.2 nCPM

Immune cell

  • classical monocyte: 11 nTPM
  • intermediate monocyte: 7.2 nTPM
  • non-classical monocyte: 6.4 nTPM
  • basophil: 6.3 nTPM
  • eosinophil: 5.2 nTPM
  • myeloid DC: 3 nTPM

Brain region

  • pons: 31 nTPM
  • choroid plexus: 28 nTPM
  • cerebellum: 27 nTPM
  • midbrain: 27 nTPM
  • thalamus: 27 nTPM
  • medulla oblongata: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.59
gnomAD pLI
0
gnomAD missense Z
0.04
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GBGT1 as an antibody target. Whether an autoantibody or antibody against GBGT1 could matter depends on whether native GBGT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GBGT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GBGT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GBGT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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