GATD1
Glutamine amidotransferase-like class 1 domain-containing protein 1
Also known as: FLJ34283, GALD1_HUMAN, PDDC1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8NB37
- Gene
- GATD1
- Ensembl
- ENSG00000177225
- Chromosome
- 11
- Canonical length
- 220 aa
- Protein class
- Enzymes, Predicted intracellular proteins, Predicted secreted proteins
- Subcellular location
- Nucleoplasm
- Secretome location
- Secreted to blood
- Quaternary structure
- Homotetramer
OverviewNCBI Gene
Predicted to enable glyoxalase III activity. Predicted to be involved in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
220 residues, UniProt reviewed canonical sequence.
>Q8NB37|GATD1
1 MASERLPNRP ACLLVASGAA EGVSAQSFLH CFTMASTAFN LQVATPGGKA MEFVDVTESN
61 ARWVQDFRLK AYASPAKLES IDGARYHALL IPSCPGALTD LASSGSLARI LQHFHSESKP
121 ICAVGHGVAA LCCATNEDRS WVFDSYSLTG PSVCELVRAP GFARLPLVVE DFVKDSGACF
181 SASEPDAVHV VLDRHLVTGQ NASSTVPAVQ NLLFLCGSRKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GATD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.25
- Highest tissue expression
- 40 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 40 nTPM
- cerebral cortex: 36 nTPM
- adrenal gland: 35 nTPM
- hippocampal formation: 32 nTPM
- basal ganglia: 31 nTPM
- amygdala: 31 nTPM
Single-cell type
- epididymal principal cells: 37 nCPM
- astrocytes: 34 nCPM
- choroid plexus epithelial cells: 32 nCPM
- alveolar cells type 1: 28 nCPM
- early primary spermatocytes: 25 nCPM
- erythrocyte progenitors: 25 nCPM
Immune cell
- myeloid DC: 6.9 nTPM
- intermediate monocyte: 6.6 nTPM
- classical monocyte: 5.2 nTPM
- plasmacytoid DC: 4 nTPM
- memory CD4 T-cell: 3.1 nTPM
- gdT-cell: 2.9 nTPM
Brain region
- medulla oblongata: 77 nTPM
- thalamus: 76 nTPM
- midbrain: 68 nTPM
- spinal cord: 60 nTPM
- cerebral cortex: 58 nTPM
- amygdala: 58 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.63
- gnomAD pLI
- 0.46
- DepMap mean gene effect
- -0.06
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- glyoxalase III activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GATD1 as an antibody target. Whether an autoantibody or antibody against GATD1 could matter depends on whether native GATD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GATD1 is annotated as secreted, so native GATD1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label GATD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...