GAST

Protein identityUniProt · HPA

UniProt accession

P01350

Gene

GAST

Ensembl

ENSG00000184502

Chromosome

17

Canonical length

101 aa

Protein class

Cancer-related genes, FDA approved drug targets, Predicted secreted proteins

Secretome location

Secreted to digestive system

OverviewNCBI Gene

Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

101 residues, UniProt reviewed canonical sequence.

>P01350|GAST
     1  MQRLCVYVLI FALALAAFSE ASWKPRSQQP DAPLGTGANR DLELPWLEQQ GPASHHRRQL
    61  GPQGPPHLVA DPSKKQGPWL EEEEEAYGWM DFGRRSAEDE N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GAST can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.67

Highest tissue expression

9,038 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for GAST from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.71

gnomAD pLI

0

gnomAD missense Z

0.05

DepMap mean gene effect

0

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• G protein-coupled receptor signaling pathway
• response to food
• signal transduction

Molecular functions

• hormone activity

Cellular components

• extracellular region
• extracellular space

Protein domainsUniProt · Pfam · InterPro

• Gastrin/cholecystokinin peptide hormone
• Gastrin/cholecystokinin, conserved site
• Gastrin/cholecystokinin family
• Gastrin

KeywordsUniProt

• Amidation
• Cleavage on pair of basic residues
• Hormone
• Phosphoprotein
• Pyrrolidone carboxylic acid
• Secreted
• Signal
• Sulfation