Seroatlas · Human Serome Atlas

GASK1B

Golgi-associated kinase 1B

Also known as: C4orf18, DKFZp434L142, ENED, FAM198B, FLJ38155, GAK1B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UWH4
Gene: GASK1B
Ensembl: ENSG00000164125
Chromosome: 4
Canonical length: 519 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Golgi apparatus,Cytosol

OverviewNCBI Gene

Located in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

519 residues, UniProt reviewed canonical sequence.

>Q6UWH4|GASK1B
     1  MTCPDKPGQL INWFICSLCV PRVRKLWSSR RPRTRRNLLL GTACAIYLGF LVSQVGRASL
    61  QHGQAAEKGP HRSRDTAEPS FPEIPLDGTL APPESQGNGS TLQPNVVYIT LRSKRSKPAN
   121  IRGTVKPKRR KKHAVASAAP GQEALVGPSL QPQEAAREAD AVAPGYAQGA NLVKIGERPW
   181  RLVRGPGVRA GGPDFLQPSS RESNIRIYSE SAPSWLSKDD IRRMRLLADS AVAGLRPVSS
   241  RSGARLLVLE GGAPGAVLRC GPSPCGLLKQ PLDMSEVFAF HLDRILGLNR TLPSVSRKAE
   301  FIQDGRPCPI ILWDASLSSA SNDTHSSVKL TWGTYQQLLK QKCWQNGRVP KPESGCTEIH
   361  HHEWSKMALF DFLLQIYNRL DTNCCGFRPR KEDACVQNGL RPKCDDQGSA ALAHIIQRKH
   421  DPRHLVFIDN KGFFDRSEDN LNFKLLEGIK EFPASAVSVL KSQHLRQKLL QSLFLDKVYW
   481  ESQGGRQGIE KLIDVIEHRA KILITYINAH GVKVLPMNE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GASK1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 195 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 195 nTPM
ovary: 128 nTPM
heart muscle: 73 nTPM
endometrium: 73 nTPM
adipose tissue: 69 nTPM
smooth muscle: 66 nTPM

Single-cell type

adrenal cortex cells: 407 nCPM
monocytes: 193 nCPM
kupffer cells: 186 nCPM
vascular endothelial cells: 153 nCPM
cardiomyocytes: 146 nCPM
monocyte progenitors: 136 nCPM

Immune cell

classical monocyte: 51 nTPM
intermediate monocyte: 29 nTPM
total PBMC: 18 nTPM
myeloid DC: 15 nTPM
non-classical monocyte: 14 nTPM
neutrophil: 0.8 nTPM

Brain region

medulla oblongata: 113 nTPM
thalamus: 78 nTPM
spinal cord: 75 nTPM
midbrain: 72 nTPM
white matter: 70 nTPM
hypothalamus: 65 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GASK1B as an antibody target. Whether an autoantibody or antibody against GASK1B could matter depends on whether native GASK1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GASK1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GASK1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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