Seroatlas · Human Serome Atlas

GASK1A

Golgi-associated kinase 1A

Also known as: C3orf41, DKFZP434B172, FAM198A, GAK1A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UFP1
Gene: GASK1A
Ensembl: ENSG00000144649
Chromosome: 3
Canonical length: 575 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Vesicles
Secretome location: Secreted - unknown location

OverviewNCBI Gene

Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

575 residues, UniProt reviewed canonical sequence.

>Q9UFP1|GASK1A
     1  MASWLRRKLR GKRRPVIAFC LLMILSAMAV TRFPPQRPSA GPDPGPMEPQ GVTGAPATHI
    61  RQALSSSRRQ RARNMGFWRS RALPRNSILV CAEEQGHRAR VDRSRESPGG DLRHPGRVRR
   121  DITLSGHPRL STQHVVLLRE DEVGDPGTKD LGHPQHGSPI QETQSEVVTL VSPLPGSDMA
   181  ALPAWRATSG LTLWPHTAEG RDLLGAENRA LTGGQQAEDP TLASGAHQWP GSVEKLQGSV
   241  WCDAETLLSS SRTGGQAPPW LTDHDVQMLR LLAQGEVVDK ARVPAHGQVL QVGFSTEAAL
   301  QDLSSPRLSQ LCSQGLCGLI KRPGDLPEVL SFHVDRVLGL RRSLPAVARR FHSPLLPYRY
   361  TDGGARPVIW WAPDVQHLSD PDEDQNSLAL GWLQYQALLA HSCNWPGQAP CPGIHHTEWA
   421  RLALFDFLLQ VHDRLDRYCC GFEPEPSDPC VEERLREKCQ NPAELRLVHI LVRSSDPSHL
   481  VYIDNAGNLQ HPEDKLNFRL LEGIDGFPES AVKVLASGCL QNMLLKSLQM DPVFWESQGG
   541  AQGLKQVLQT LEQRGQVLLG HIQKHNLTLF RDEDP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GASK1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 8.4 nTPM

Expression across tissuesHPA

Tissue

liver: 8.4 nTPM
choroid plexus: 7.9 nTPM
endometrium: 7.4 nTPM
fallopian tube: 6.6 nTPM
cervix: 5 nTPM
adipose tissue: 4.6 nTPM

Single-cell type

peritubular myoid cells: 44 nCPM
decidual stromal cells: 35 nCPM
hepatocytes: 28 nCPM
bergmann glia: 26 nCPM
leydig cells: 25 nCPM
fallopian tube ciliated cells: 24 nCPM

Immune cell

plasmacytoid DC: 0.2 nTPM
basophil: 0.1 nTPM
myeloid DC: 0.1 nTPM
naive B-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
neutrophil: 0.1 nTPM

Brain region

thalamus: 21 nTPM
medulla oblongata: 19 nTPM
midbrain: 17 nTPM
spinal cord: 14 nTPM
pons: 14 nTPM
cerebellum: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.59
gnomAD pLI: 0
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GASK1A as an antibody target. Whether an autoantibody or antibody against GASK1A could matter depends on whether native GASK1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GASK1A is annotated as secreted, so native GASK1A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label GASK1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...