Seroatlas · Human Serome Atlas

GAS8-AS1

Uncharacterized protein GAS8-AS1

Also known as: GAAS1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95177
Gene: GAS8-AS1
Canonical length: 125 aa

OverviewNCBI Gene

No narrative summary is available for GAS8-AS1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

125 residues, UniProt reviewed canonical sequence.

>O95177|GAS8-AS1
     1  MKLSSAAGQE SPGHPHPSPP AWTLKKPSES VAQRAMCSAR ACPVACPVGC PAACPVGCPI
    61  ACPVSCPVAC PVGCPVGSMA TAPQGLSPQE WEADRETGSS SHAGTTQCSI HSPSSSSRHL
   121  SRTQT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GAS8-AS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

KeywordsUniProt

Repeat

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GAS8-AS1 as an antibody target. Whether an autoantibody or antibody against GAS8-AS1 could matter depends on whether native GAS8-AS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GAS8-AS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GAS8-AS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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