Seroatlas · Human Serome Atlas

GAS1

Growth arrest-specific protein 1

Also known as: GAS1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P54826
Gene: GAS1
Ensembl: ENSG00000180447
Chromosome: 9
Canonical length: 345 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

345 residues, UniProt reviewed canonical sequence.

>P54826|GAS1
     1  MVAALLGGGG EARGGTVPGA WLCLMALLQL LGSAPRGSGL AHGRRLICWQ ALLQCQGEPE
    61  CSYAYNQYAE ACAPVLAQHG GGDAPGAAAA AFPASAASFS SRWRCPSHCI SALIQLNHTR
   121  RGPALEDCDC AQDENCKSTK RAIEPCLPRT SGGGAGGPGA GGVMGCTEAR RRCDRDSRCN
   181  LALSRYLTYC GKVFNGLRCT DECRTVIEDM LAMPKAALLN DCVCDGLERP ICESVKENMA
   241  RLCFGAELGN GPGSSGSDGG LDDYYDEDYD DEQRTGGAGG EQPLDDDDGV PHPPRPGSGA
   301  AASGGRGDLP YGPGRRSSGG GGRLAPRGAW TPLASILLLL LGPLF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GAS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 81 nTPM

Expression across tissuesHPA

Tissue

endometrium: 81 nTPM
adipose tissue: 69 nTPM
fallopian tube: 52 nTPM
smooth muscle: 41 nTPM
ovary: 37 nTPM
breast: 33 nTPM

Single-cell type

decidual stromal cells: 272 nCPM
fibroblasts: 166 nCPM
mesothelial cells: 147 nCPM
medullary thymic epithelial cells: 122 nCPM
breast myoepithelial cells: 112 nCPM
müller glia: 100 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 33 nTPM
white matter: 13 nTPM
basal ganglia: 8.2 nTPM
cerebral cortex: 7.9 nTPM
midbrain: 7 nTPM
medulla oblongata: 6.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.53
gnomAD pLI: 0.82
gnomAD missense Z: 0.75
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

oxysterol binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

GDNF/GAS1
GDNF/GAS1 domain
Growth arrest-specific protein 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GAS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CDON

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GAS1 as an antibody target. Whether an autoantibody or antibody against GAS1 could matter depends on whether native GAS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GAS1 is annotated at the cell surface, where native GAS1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GAS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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