Seroatlas · Human Serome Atlas

GAREM2

GRB2-associated and regulator of MAPK protein 2

Also known as: FAM59B, FLJ00375, GARE2_HUMAN, GAREML, KIAA2038

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q75VX8
Gene: GAREM2
Ensembl: ENSG00000157833
Chromosome: 2
Canonical length: 874 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to act upstream of or within several processes, including cognition; neuron projection extension; and social behavior. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

874 residues, UniProt reviewed canonical sequence.

>Q75VX8|GAREM2
     1  MEKLAAGLAG LRWSMGAFPL DLIVSRCRLP TLACLGPGEY AEGVSERDIL LIHSCRQWTT
    61  VTAHTLEEGH YVIGPKIDIP LQYPGKFKLL EQARDVREPV RYFSSVEEVA SVFPDRIFVM
   121  EAITFSVKVV SGEFSEDSEV YNFTLHAGDE LTLMGQAEIL CAKTTKERSR FTTLLRKLGR
   181  AGALAGVGGG GPASAGAAGG TGGGGARPVK GKMPCLICMN HRTNESLSLP FQCQGRFSTR
   241  SPLELQMQEG EHTVRAIIER VRLPVNVLVP SRPPRNPYDL HPVREGHCYK LVSIISKTVV
   301  LGLALRREGP APLHFLLLTD TPRFALPQGL LAGDPRVERL VRDSASYCRE RFDPDEYSTA
   361  VREAPAELAE DCASPRRARL CLPAPRAPGL ARAPGPLAPA PAGEGDQEYV SPDWAAAPEP
   421  AAPPAEIPYE ELWAHQGPEG LVRPPPGLDL ISFGAAGPPR REPEAPPPPV PPKSEAVKEE
   481  CRLLNAPPVP PRGGNGSGRL SSSPPVPPRF PKLQPVHSPS SSLSYYSSGL QDGAGSRSGS
   541  GSPSPDTYSL YCYPCTWGDC KVGESSSRPA PGPLPSTTQP SQASRALTEP LSGRAASLLG
   601  ADTPVKTYHS CPPLFKPSHP QKRFAPFGAL NPFSGPAYPS GPSAALSSGP RTTSGPVATS
   661  GPAYSPGPAS PGQAYSAAPP SSCAPSSSSS SEWQEPVLEP FDPFELGQGS SPEPELLRSQ
   721  EPRAVGTPGP GPRLSPLGPS KAFEPEGLVL HQVPTPLSPA ALQGPEAGGA LFLTQGRLEG
   781  PPASPRDGAT GFGVRDASSW QPPADLSALS LEEVSRSLRF IGLSEDVVSF FARERIDGSI
   841  FVQLSEDILA DDFHLTKLQV KKIMQFIKGW RPKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GAREM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 24 nTPM
amygdala: 23 nTPM
cerebral cortex: 22 nTPM
parathyroid gland: 22 nTPM
midbrain: 21 nTPM
hypothalamus: 18 nTPM

Single-cell type

astrocytes: 52 nCPM
bergmann glia: 40 nCPM
müller glia: 32 nCPM
early spermatids: 12 nCPM
oligodendrocyte progenitor cells: 12 nCPM
late spermatids: 11 nCPM

Immune cell

plasmacytoid DC: 0.5 nTPM
memory CD4 T-cell: 0.3 nTPM
gdT-cell: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM
naive CD4 T-cell: 0.2 nTPM
neutrophil: 0.2 nTPM

Brain region

thalamus: 63 nTPM
medulla oblongata: 54 nTPM
midbrain: 52 nTPM
basal ganglia: 49 nTPM
cerebellum: 48 nTPM
pons: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0.44
DepMap mean gene effect: -0.11
DepMap dependency class: selective

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GAREM2 as an antibody target. Whether an autoantibody or antibody against GAREM2 could matter depends on whether native GAREM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GAREM2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GAREM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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