GAPT
Protein GAPT
Also known as: C5orf29, FLJ33641, GAPT_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N292
- Gene
- GAPT
- Ensembl
- ENSG00000175857
- Chromosome
- 5
- Canonical length
- 157 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Golgi apparatus,Vesicles,Plasma membrane
OverviewNCBI Gene
Predicted to be involved in B cell homeostasis and B cell proliferation involved in immune response. Located in Golgi apparatus and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
157 residues, UniProt reviewed canonical sequence.
>Q8N292|GAPT
1 MSKSCGNNLA AISVGISLLL LLVVCGIGCV WHWKHRVATR FTLPRFLQRR SSRRKVCTKT
61 FLGPRIIGLR HEISVETQDH KSAVRGNNTH DNYENVEAGP PKAKGKTDKE LYENTGQSNF
121 EEHIYGNETS SDYYNFQKPR PSEVPQDEDI YILPDSYLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GAPT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.68
- Highest tissue expression
- 28 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 28 nTPM
- appendix: 21 nTPM
- lymph node: 18 nTPM
- spleen: 13 nTPM
- bone marrow: 11 nTPM
- thymus: 4.6 nTPM
Single-cell type
- pdcs: 206 nCPM
- neutrophils: 159 nCPM
- monocyte progenitors: 98 nCPM
- neutrophil progenitors: 71 nCPM
- mast cells: 67 nCPM
- b-cells: 66 nCPM
Immune cell
- eosinophil: 647 nTPM
- plasmacytoid DC: 140 nTPM
- basophil: 92 nTPM
- naive B-cell: 65 nTPM
- memory B-cell: 64 nTPM
- neutrophil: 54 nTPM
Brain region
- white matter: 3.9 nTPM
- choroid plexus: 3.3 nTPM
- medulla oblongata: 3.2 nTPM
- midbrain: 2.9 nTPM
- thalamus: 2.9 nTPM
- spinal cord: 2.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.87
- gnomAD pLI
- 0.31
- gnomAD missense Z
- -0.34
- DepMap mean gene effect
- -0.07
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Protein GAPT
- GRB2-binding adapter (GAPT)
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of GAPT in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GAPT as an antibody target. Whether an autoantibody or antibody against GAPT could matter depends on whether native GAPT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GAPT is annotated at the cell surface, where native GAPT is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label GAPT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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