Seroatlas · Human Serome Atlas

GALR3

Galanin receptor type 3

Also known as: GALR3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60755
Gene: GALR3
Ensembl: ENSG00000128310
Chromosome: 22
Canonical length: 368 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

368 residues, UniProt reviewed canonical sequence.

>O60755|GALR3
     1  MADAQNISLD SPGSVGAVAV PVVFALIFLL GTVGNGLVLA VLLQPGPSAW QEPGSTTDLF
    61  ILNLAVADLC FILCCVPFQA TIYTLDAWLF GALVCKAVHL LIYLTMYASS FTLAAVSVDR
   121  YLAVRHPLRS RALRTPRNAR AAVGLVWLLA ALFSAPYLSY YGTVRYGALE LCVPAWEDAR
   181  RRALDVATFA AGYLLPVAVV SLAYGRTLRF LWAAVGPAGA AAAEARRRAT GRAGRAMLAV
   241  AALYALCWGP HHALILCFWY GRFAFSPATY ACRLASHCLA YANSCLNPLV YALASRHFRA
   301  RFRRLWPCGR RRRHRARRAL RRVRPASSGP PGCPGDARPS GRLLAGGGQG PEPREGPVHG
   361  GEAARGPE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GALR3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 0.4 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 0.4 nTPM
basal ganglia: 0.3 nTPM
pancreas: 0.3 nTPM
skeletal muscle: 0.3 nTPM
hypothalamus: 0.2 nTPM
liver: 0.2 nTPM

Single-cell type

late spermatids: 3.2 nCPM
epicardial cells: 2.3 nCPM
other brain neurons: 1.9 nCPM
endometrial glandular cells: 1.4 nCPM
late primary spermatocytes: 1.1 nCPM
megakaryocyte-erythroid progenitors: 1.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 2.3 nTPM
cerebellum: 2.1 nTPM
cerebral cortex: 1.3 nTPM
basal ganglia: 1.2 nTPM
amygdala: 1.1 nTPM
midbrain: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.71
gnomAD pLI: 0
gnomAD missense Z: 0.21
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GALR3 as an antibody target. Whether an autoantibody or antibody against GALR3 could matter depends on whether native GALR3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GALR3 is annotated at the cell surface, where native GALR3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GALR3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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