Seroatlas · Human Serome Atlas

GALP

Galanin-like peptide

Also known as: GALP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UBC7
Gene: GALP
Ensembl: ENSG00000197487
Chromosome: 19
Canonical length: 116 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in brain

OverviewNCBI Gene

This gene encodes a member of the galanin family of neuropeptides. The encoded protein binds galanin receptors 1, 2 and 3 with the highest affinity for galanin receptor 3 and has been implicated in biological processes involving the central nervous system including hypothalamic regulation of metabolism and reproduction. A peptide encoded by a splice variant of this gene, termed alarin, has vasoactive properties, displays antimicrobial activity against E. coli, and may serve as a marker for neuroblastic tumors.[provided by RefSeq, Nov 2014]

Canonical amino-acid sequenceUniProt

116 residues, UniProt reviewed canonical sequence.

>Q9UBC7|GALP
     1  MAPPSVPLVL LLVLLLSLAE TPASAPAHRG RGGWTLNSAG YLLGPVLHLP QMGDQDGKRE
    61  TALEILDLWK AIDGLPYSHP PQPSKRNVME TFAKPEIGDL GMLSMKIPKE EDVLKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GALP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 0.6 nTPM

Expression across tissuesHPA

Tissue

liver: 0.6 nTPM
amygdala: 0.2 nTPM
basal ganglia: 0.2 nTPM
hippocampal formation: 0.1 nTPM
hypothalamus: 0.1 nTPM
midbrain: 0.1 nTPM

Single-cell type

retinal pigment epithelial cells: 4.3 nCPM
parietal cells: 1.8 nCPM
undifferentiated spermatogonia: 1.7 nCPM
endometrial glandular cells: 1 nCPM
thymocytes: 0.8 nCPM
hepatocytes: 0.6 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 0.7 nTPM
amygdala: 0.6 nTPM
cerebral cortex: 0.6 nTPM
basal ganglia: 0.3 nTPM
hypothalamus: 0.3 nTPM
midbrain: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.7
gnomAD pLI: 0
gnomAD missense Z: -0.18
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

Galanin
Galanin
Galanin-like peptide

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GALP as an antibody target. Whether an autoantibody or antibody against GALP could matter depends on whether native GALP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GALP is annotated as secreted, so native GALP circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label GALP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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