Seroatlas · Human Serome Atlas

GALNTL6

Polypeptide N-acetylgalactosaminyltransferase-like 6

Also known as: GalNAc-T6L, GALNT17, GLTL6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q49A17
Gene
GALNTL6
Ensembl
ENSG00000174473
Chromosome
4
Canonical length
601 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

Enables polypeptide N-acetylgalactosaminyltransferase activity. Involved in protein O-linked glycosylation via threonine. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

601 residues, UniProt reviewed canonical sequence.

>Q49A17|GALNTL6
     1  MKRKQKRFLQ MTLLFTVALI FLPNVGLWSL YKDKHLVKSA EPGEQQTFPL GLGDGQFYSW
    61  TDGLRRKDWH DYESIQKEAM RSGKGEHGKP YPLTEEDHDD SAYRENGFNI FVSNNIALER
   121  SLPDIRHANC KHKMYLERLP NTSIIIPFHN EGWTSLLRTI HSIINRTPGS LIAEIILVDD
   181  FSEREHLKDK LEEYMARFSK VRIVRTKKRE GLIRTRLLGA SMARGEVLTF LDSHCEVNVN
   241  WLPPLLNQIA LNHKTIVCPM IDVIDHNHFG YEAQAGDAMR GAFDWEMYYK RIPIPPELQR
   301  ADPSDPFESP VMAGGLFAVD RKWFWELGGY DPGLEIWGGE QYEISFKVWM CGGEMFDVPC
   361  SRVGHIYRKY VPYKVPSGTS LARNLKRVAE TWMDEFAEYI YQRRPEYRHL STGDISAQKE
   421  LRKQLKCKDF KWFMAAVAWD VPKYYPPVEP PPAAWGEIRN VAANLCVDSK HGATGTELRL
   481  DICVKDGSER TWSHEQLFTF GWREDIRPGE PLHTRKFCFD AISHNSPVTL YDCHGMKGNQ
   541  LWGYRKDRTL FHPVSNSCMD CNPAEKKIFM ARCDPLSETQ QWIFEHINMT VLEKFNHHAN
   601  S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GALNTL6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
3.9 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 3.9 nTPM
  • midbrain: 3.8 nTPM
  • cerebral cortex: 3.1 nTPM
  • hypothalamus: 2.4 nTPM
  • spleen: 2.4 nTPM
  • testis: 2.3 nTPM

Single-cell type

  • brain inhibitory neurons: 2,135 nCPM
  • brain excitatory neurons: 1,114 nCPM
  • retinal ganglion cells: 1,008 nCPM
  • other brain neurons: 934 nCPM
  • melanocytes: 389 nCPM
  • retinal amacrine cells: 181 nCPM

Immune cell

  • memory B-cell: 1.6 nTPM
  • naive B-cell: 0.5 nTPM
  • myeloid DC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • hypothalamus: 22 nTPM
  • cerebral cortex: 18 nTPM
  • midbrain: 17 nTPM
  • thalamus: 15 nTPM
  • basal ganglia: 14 nTPM
  • pons: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.82
gnomAD pLI
0
gnomAD missense Z
2.14
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GALNTL6 as an antibody target. Whether an autoantibody or antibody against GALNTL6 could matter depends on whether native GALNTL6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GALNTL6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GALNTL6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GALNTL6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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