Seroatlas · Human Serome Atlas

GALNTL5

Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5

Also known as: GalNAc-T5L, GALNT15, GLTL5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z4T8
Gene: GALNTL5
Ensembl: ENSG00000106648
Chromosome: 7
Canonical length: 443 aa
Protein class: Disease related genes, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable metal ion binding activity and transferase activity. Involved in spermatid development. Predicted to be located in late endosome membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

443 residues, UniProt reviewed canonical sequence.

>Q7Z4T8|GALNTL5
     1  MRNAIIQGLF YGSLTFGIWT ALLFIYLHHN HVSSWQKKSQ EPLSAWSPGK KVHQQIIYGS
    61  EQIPKPHVIV KRTDEDKAKS MLGTDFNHTN PELHKELLKY GFNVIISRSL GIEREVPDTR
   121  SKMCLQKHYP ARLPTASIVI CFYNEECNAL FQTMSSVTNL TPHYFLEEII LVDDMSKVDD
   181  LKEKLDYHLE TFRGKVKIIR NKKREGLIRA RLIGASHASG DVLVFLDSHC EVNRVWLEPL
   241  LHAIAKDPKM VVCPLIDVID DRTLEYKPSP LVRGTFDWNL QFKWDNVFSY EMDGPEGSTK
   301  PIRSPAMSGG IFAIRRHYFN EIGQYDKDMD FWGRENLELS LRIWMCGGQL FIIPCSRVGH
   361  ISKKQTGKPS TIISAMTHNY LRLVHVWLDE YKEQFFLRKP GLKYVTYGNI RERVELRKRL
   421  GCKSFQWYLD NVFPELEASV NSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GALNTL5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

testis: 11 nTPM
cerebral cortex: 1.6 nTPM
amygdala: 0.9 nTPM
hippocampal formation: 0.7 nTPM
basal ganglia: 0.5 nTPM
adipose tissue: 0 nTPM

Single-cell type

late spermatids: 876 nCPM
early spermatids: 659 nCPM
late primary spermatocytes: 214 nCPM
tuft cells: 12 nCPM
epicardial cells: 2.3 nCPM
retinal bipolar cells: 2.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.5 nTPM
white matter: 0.5 nTPM
basal ganglia: 0.2 nTPM
amygdala: 0.1 nTPM
hippocampal formation: 0.1 nTPM
cerebellum: 0 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GALNTL5.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 91 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Male infertility

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.63
gnomAD pLI: 0
gnomAD missense Z: -0.79
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

spermatid development

Molecular functions

metal ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GALNTL5 as an antibody target. Whether an autoantibody or antibody against GALNTL5 could matter depends on whether native GALNTL5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GALNTL5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GALNTL5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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