Seroatlas · Human Serome Atlas

GALNT5

Polypeptide N-acetylgalactosaminyltransferase 5

Also known as: GalNAc-T5, GALT5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z7M9
Gene: GALNT5
Ensembl: ENSG00000136542
Chromosome: 2
Canonical length: 940 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoli,Golgi apparatus,Vesicles,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a membrane-bound polypeptide N-acetylgalactosaminyltransferase that is found in the Golgi. The encoded protein catalyzes the first step in the mucin-type O-glycosylation of Golgi proteins, transfering an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

940 residues, UniProt reviewed canonical sequence.

>Q7Z7M9|GALNT5
     1  MNRIRKFFRG SGRVLAFIFV ASVIWLLFDM AALRLSFSEI NTRVIKEDIV RRERIGFRVQ
    61  PDQGKIFYSS IKEMKPPLRG HGKGAWGKEN VRKTEESVLK VEVDLDQTQR ERKMQNALGR
   121  GKVVPLWHPA HLQTLPVTPN KQKTDGRGTK PEASSHQGTP KQTTAQGAPK TSFIAAKGTQ
   181  VVKISVHMGR VSLKQEPRKS HSPSSDTSKL AAERDLNVTI SLSTDRPKQR SQAVANERAH
   241  PASTAVPKSG EAMALNKTKT QSKEVNANKH KANTSLPFPK FTVNSNRLRK QSINETPLGS
   301  LSKDDGARGA HGKKLNFSES HLVIITKEEE QKADPKEVSN SKTKTIFPKV LGKSQSKHIS
   361  RNRSEMSSSS LAPHRVPLSQ TNHALTGGLE PAKINITAKA PSTEYNQSHI KALLPEDSGT
   421  HQVLRIDVTL SPRDPKAPGQ FGRPVVVPHG KEKEAERRWK EGNFNVYLSD LIPVDRAIED
   481  TRPAGCAEQL VHNNLPTTSV IMCFVDEVWS TLLRSVHSVI NRSPPHLIKE ILLVDDFSTK
   541  DYLKDNLDKY MSQFPKVRIL RLKERHGLIR ARLAGAQNAT GDVLTFLDSH VECNVGWLEP
   601  LLERVYLSRK KVACPVIEVI NDKDMSYMTV DNFQRGIFVW PMNFGWRTIP PDVIAKNRIK
   661  ETDTIRCPVM AGGLFSIDKS YFFELGTYDP GLDVWGGENM ELSFKVWMCG GEIEIIPCSR
   721  VGHIFRNDNP YSFPKDRMKT VERNLVRVAE VWLDEYKELF YGHGDHLIDQ GLDVGNLTQQ
   781  RELRKKLKCK SFKWYLENVF PDLRAPIVRA SGVLINVALG KCISIENTTV ILEDCDGSKE
   841  LQQFNYTWLR LIKCGEWCIA PIPDKGAVRL HPCDNRNKGL KWLHKSTSVF HPELVNHIVF
   901  ENNQQLLCLE GNFSQKILKV AACDPVKPYQ KWKFEKYYEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GALNT5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

rectum: 13 nTPM
stomach: 12 nTPM
colon: 10 nTPM
lung: 9.6 nTPM
salivary gland: 6.6 nTPM
esophagus: 4.2 nTPM

Single-cell type

goblet cells: 257 nCPM
alveolar cells type 1: 220 nCPM
foveolar cells: 147 nCPM
ocular epithelial cells: 105 nCPM
salivary basal cells: 102 nCPM
esophageal apical cells: 93 nCPM

Immune cell

neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

choroid plexus: 12 nTPM
cerebellum: 8.9 nTPM
hippocampal formation: 1.4 nTPM
cerebral cortex: 1.2 nTPM
pons: 1.1 nTPM
white matter: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0
gnomAD missense Z: 0.48
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GALNT5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

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Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GALNT5 as an antibody target. Whether an autoantibody or antibody against GALNT5 could matter depends on whether native GALNT5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GALNT5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GALNT5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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