Seroatlas · Human Serome Atlas

GALNT16

Polypeptide N-acetylgalactosaminyltransferase 16

Also known as: GalNAc-T16, GALNTL1, GLT16_HUMAN, KIAA1130

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N428
Gene
GALNT16
Ensembl
ENSG00000100626
Chromosome
14
Canonical length
558 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Vesicles,Cytosol

OverviewNCBI Gene

Enables polypeptide N-acetylgalactosaminyltransferase activity. Involved in protein O-linked glycosylation via serine and protein O-linked glycosylation via threonine. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

558 residues, UniProt reviewed canonical sequence.

>Q8N428|GALNT16
     1  MRKIRANAIA ILTVAWILGT FYYLWQDNRA HAASSGGRGA QRAGRRSEQL REDRTIPLIV
    61  TGTPSKGFDE KAYLSAKQLK AGEDPYRQHA FNQLESDKLS PDRPIRDTRH YSCPSVSYSS
   121  DLPATSVIIT FHNEARSTLL RTVKSVLNRT PANLIQEIIL VDDFSSDPED CLLLTRIPKV
   181  KCLRNDRREG LIRSRVRGAD VAAATVLTFL DSHCEVNTEW LPPMLQRVKE DHTRVVSPII
   241  DVISLDNFAY LAASADLRGG FDWSLHFKWE QIPLEQKMTR TDPTRPIRTP VIAGGIFVID
   301  KSWFNHLGKY DAQMDIWGGE NFELSFRVWM CGGSLEIVPC SRVGHVFRKR HPYNFPEGNA
   361  LTYIRNTKRT AEVWMDEYKQ YYYEARPSAI GKAFGSVATR IEQRKKMNCK SFRWYLENVY
   421  PELTVPVKEA LPGIIKQGVN CLESQGQNTA GDFLLGMGIC RGSAKNPQPA QAWLFSDHLI
   481  QQQGKCLAAT STLMSSPGSP VILQMCNPRE GKQKWRRKGS FIQHSVSGLC LETKPAQLVT
   541  SKCQADAQAQ QWQLLPHT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GALNT16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
47 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 47 nTPM
  • hypothalamus: 32 nTPM
  • basal ganglia: 24 nTPM
  • hippocampal formation: 22 nTPM
  • salivary gland: 22 nTPM
  • cerebral cortex: 20 nTPM

Single-cell type

  • cardiomyocytes: 83 nCPM
  • fibro-adipogenic progenitors: 57 nCPM
  • ependymal cells: 53 nCPM
  • other brain neurons: 53 nCPM
  • early spermatids: 46 nCPM
  • brain inhibitory neurons: 41 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 74 nTPM
  • cerebral cortex: 46 nTPM
  • hippocampal formation: 45 nTPM
  • basal ganglia: 43 nTPM
  • midbrain: 38 nTPM
  • amygdala: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.59
gnomAD pLI
0
gnomAD missense Z
1.3
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GALNT16 as an antibody target. Whether an autoantibody or antibody against GALNT16 could matter depends on whether native GALNT16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GALNT16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GALNT16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GALNT16. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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