Seroatlas · Human Serome Atlas

GALNT15

Polypeptide N-acetylgalactosaminyltransferase 15

Also known as: GALNT7, GALNTL2, GLT15_HUMAN, pp-GalNAc-T15

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N3T1
Gene
GALNT15
Ensembl
ENSG00000131386
Chromosome
3
Canonical length
639 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Golgi apparatus,Cytosol

OverviewNCBI Gene

Predicted to enable polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation. Located in transport vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

639 residues, UniProt reviewed canonical sequence.

>Q8N3T1|GALNT15
     1  MLLRKRYRHR PCRLQFLLLL LMLGCVLMMV AMLHPPHHTL HQTVTAQASK HSPEARYRLD
    61  FGESQDWVLE AEDEGEEYSP LEGLPPFISL REDQLLVAVA LPQARRNQSQ GRRGGSYRLI
   121  KQPRRQDKEA PKRDWGADED GEVSEEEELT PFSLDPRGLQ EALSARIPLQ RALPEVRHPL
   181  CLQQHPQDSL PTASVILCFH DEAWSTLLRT VHSILDTVPR AFLKEIILVD DLSQQGQLKS
   241  ALSEYVARLE GVKLLRSNKR LGAIRARMLG ATRATGDVLV FMDAHCECHP GWLEPLLSRI
   301  AGDRSRVVSP VIDVIDWKTF QYYPSKDLQR GVLDWKLDFH WEPLPEHVRK ALQSPISPIR
   361  SPVVPGEVVA MDRHYFQNTG AYDSLMSLRG GENLELSFKA WLCGGSVEIL PCSRVGHIYQ
   421  NQDSHSPLDQ EATLRNRVRI AETWLGSFKE TFYKHSPEAF SLSKAEKPDC MERLQLQRRL
   481  GCRTFHWFLA NVYPELYPSE PRPSFSGKLH NTGLGLCADC QAEGDILGCP MVLAPCSDSR
   541  QQQYLQHTSR KEIHFGSPQH LCFAVRQEQV ILQNCTEEGL AIHQQHWDFQ ENGMIVHILS
   601  GKCMEAVVQE NNKDLYLRPC DGKARQQWRF DQINAVDER

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GALNT15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
132 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 132 nTPM
  • spinal cord: 77 nTPM
  • breast: 74 nTPM
  • blood vessel: 56 nTPM
  • midbrain: 36 nTPM
  • skin: 34 nTPM

Single-cell type

  • fibroblasts: 301 nCPM
  • medullary thymic epithelial cells: 166 nCPM
  • vascular endothelial cells: 136 nCPM
  • myosatellite cells: 112 nCPM
  • salivary myoepithelial cells: 107 nCPM
  • fibro-adipogenic progenitors: 102 nCPM

Immune cell

  • basophil: 0.4 nTPM
  • gdT-cell: 0.2 nTPM
  • naive B-cell: 0.2 nTPM
  • naive CD8 T-cell: 0.2 nTPM
  • NK-cell: 0.2 nTPM
  • plasmacytoid DC: 0.2 nTPM

Brain region

  • medulla oblongata: 325 nTPM
  • white matter: 316 nTPM
  • pons: 257 nTPM
  • spinal cord: 245 nTPM
  • hypothalamus: 220 nTPM
  • thalamus: 160 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.28
gnomAD pLI
0
gnomAD missense Z
-0.23
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GALNT15 as an antibody target. Whether an autoantibody or antibody against GALNT15 could matter depends on whether native GALNT15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GALNT15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GALNT15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GALNT15. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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