Seroatlas · Human Serome Atlas

GALNT14

Polypeptide N-acetylgalactosaminyltransferase 14

Also known as: FLJ12691, GalNac-T10, GalNac-T14, GLT14_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96FL9
Gene
GALNT14
Ensembl
ENSG00000158089
Chromosome
2
Canonical length
552 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

This gene encodes a Golgi protein which is a member of the polypeptide N-acetylgalactosaminyltransferase (ppGalNAc-Ts) protein family. These enzymes catalyze the transfer of N-acetyl-D-galactosamine (GalNAc) to the hydroxyl groups on serines and threonines in target peptides. The encoded protein has been shown to transfer GalNAc to large proteins like mucins. Alterations in this gene may play a role in cancer progression and response to chemotherapy. [provided by RefSeq, Jun 2016]

Canonical amino-acid sequenceUniProt

552 residues, UniProt reviewed canonical sequence.

>Q96FL9|GALNT14
     1  MRRLTRRLVL PVFGVLWITV LLFFWVTKRK LEVPTGPEVQ TPKPSDADWD DLWDQFDERR
    61  YLNAKKWRVG DDPYKLYAFN QRESERISSN RAIPDTRHLR CTLLVYCTDL PPTSIIITFH
   121  NEARSTLLRT IRSVLNRTPT HLIREIILVD DFSNDPDDCK QLIKLPKVKC LRNNERQGLV
   181  RSRIRGADIA QGTTLTFLDS HCEVNRDWLQ PLLHRVKEDY TRVVCPVIDI INLDTFTYIE
   241  SASELRGGFD WSLHFQWEQL SPEQKARRLD PTEPIRTPII AGGLFVIDKA WFDYLGKYDM
   301  DMDIWGGENF EISFRVWMCG GSLEIVPCSR VGHVFRKKHP YVFPDGNANT YIKNTKRTAE
   361  VWMDEYKQYY YAARPFALER PFGNVESRLD LRKNLRCQSF KWYLENIYPE LSIPKESSIQ
   421  KGNIRQRQKC LESQRQNNQE TPNLKLSPCA KVKGEDAKSQ VWAFTYTQQI LQEELCLSVI
   481  TLFPGAPVVL VLCKNGDDRQ QWTKTGSHIE HIASHLCLDT DMFGDGTENG KEIVVNPCES
   541  SLMSQHWDMV SS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GALNT14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 39 nTPM
  • choroid plexus: 13 nTPM
  • esophagus: 13 nTPM
  • pituitary gland: 5.8 nTPM
  • bone marrow: 5.6 nTPM
  • tonsil: 4.5 nTPM

Single-cell type

  • proximal tubule cells: 656 nCPM
  • esophageal apical cells: 337 nCPM
  • loop of henle epithelial cells: 334 nCPM
  • lactotrophs: 310 nCPM
  • neutrophils: 249 nCPM
  • distal convoluted tubule cells: 200 nCPM

Immune cell

  • neutrophil: 8.5 nTPM
  • memory B-cell: 1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • thalamus: 25 nTPM
  • cerebral cortex: 24 nTPM
  • midbrain: 15 nTPM
  • amygdala: 9.5 nTPM
  • choroid plexus: 8.8 nTPM
  • white matter: 8.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GALNT14.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 122 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.1
gnomAD pLI
0
gnomAD missense Z
0.43
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GALNT14 as an antibody target. Whether an autoantibody or antibody against GALNT14 could matter depends on whether native GALNT14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GALNT14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GALNT14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GALNT14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...